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Axon Diameter Distributions (ADDs) change during brain development and are altered in several brain pathologies. Mapping ADDs non-invasively using dMRI could provide a useful biomarker, but existing methods are either parametric, orientation dependent, surmmarize the whole ADD as a single measure or use non-standard protocols. We propose to estimate the ADD from an orientation-invariant PGSE protocol optimized for axon diameter sensitivity, using a discrete linear model with smoothness and sparsity regularization. To our knowledge, we are the first to report orientationally invarant ADD estimates from dMRI data.
Maria del Carmen Sandi Perez, Bogdan Draganski