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The Human Brain Project: Creating a European Research Infrastructure to Decode the Human Brain

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A Brief History of Simulation Neuroscience

Henry Markram, Xue Fan

Our knowledge of the brain has evolved over millennia in philosophical, experimental and theoretical phases. We suggest that the next phase is simulation neuroscience. The main drivers of simulation neuroscience are big data generated at multiple levels of ...

FRONTIERS MEDIA SA2019

Dynamic organization of human brain function and its relevance for psychosis vulnerability

Daniela Maria Zöller

The brain is the substrate of a complex dynamic system providing a remarkably varied range of functionalities, going from simple perception to higher-level cognition. Disturbances in its complex dynamics can cause an equally vast variety of mental disorder ...

EPFL2019

Cell Densities in the Mouse Brain: A Systematic Review

Henry Markram, Daniel Keller, Csaba Erö

The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure ...

FRONTIERS MEDIA SA2018

Data-driven reconstruction of a point neuron mouse brain

Csaba Erö

In this work, we present a semi-automatic method to reconstruct a mouse whole-brain model at the point-neuron level by integrating a wide array of biological data. Our process has three parts: cell position and type assignment, connectivity mapping, and si ...

EPFL2018

Supercomputers, Clouds and Grids powered by BigPanDA for Brain studies

Fabien Jonathan Delalondre, Alexandre Emmanuel Francis Beche

The PanDA WMS - Production and Distributed Analysis Workload Management System - has been developed and used by the ATLAS experiment at the LHC ( Large Hadron Collider) for all data processing and analysis challenges. BigPanDA is an extension of the PanDA ...

IOP PUBLISHING LTD2018

Decreased integration and information capacity in stroke measured by whole brain models of resting state activity

Alessandra Griffa, Patric Hagmann

While several studies have shown that focal lesions affect the communication between structurally normal regions of the brain, and that these changes may correlate with behavioural deficits, their impact on brain's information processing capacity is curren ...

Oxford Univ Press2017

Reconstructing the brain: from image stacks to neuron synthesis

Sean Lewis Hill, Julian Charles Shillcock

Large-scale brain initiatives such as the US BRAIN initiative and the European Human Brain Project aim to marshall a vast amount of data and tools for the purpose of furthering our understanding of brains. Fundamental to this goal is that neuronal morpholo ...

2016

Agile in-litero experiments

Renaud Luc Richardet

In neuroscience, as in many other scientific domains, the primary form of knowledge dissemination is through published articles in peer-reviewed journals. One challenge for modern neuroinformatics is to design methods to make the knowledge from the tremend ...

EPFL2016

Feeding the human brain model

Sean Lewis Hill

The goal of the Human Brain Project is to develop, during the next decade, an infrastructure capable of simulating a draft human brain model based on available experimental data. One of the key issues is therefore to integrate and make accessible the exper ...

Elsevier2015

Task-Driven Activity Reduces the Cortical Activity Space of the Brain: Experiment and Whole-Brain Modeling

Patric Hagmann

How a stimulus or a task alters the spontaneous dynamics of the brain remains a fundamental open question in neuroscience. One of the most robust hallmarks of task/stimulus-driven brain dynamics is the decrease of variability with respect to the spontaneou ...

Public Library Science2015