Johan Auwerx, Carlos Canto Alvarez, Hiroyasu Yamamoto
SIRT1 is a NAD+-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here, we tested whether deletion of PARP-2, an alternative NAD+-consuming enzyme, impacts on NAD+ bioavailability and SIRT1 acti ...
Elsevier2011