Virtual screeningVirtual screening (VS) is a computational technique used in drug discovery to search libraries of small molecules in order to identify those structures which are most likely to bind to a drug target, typically a protein receptor or enzyme. Virtual screening has been defined as "automatically evaluating very large libraries of compounds" using computer programs. As this definition suggests, VS has largely been a numbers game focusing on how the enormous chemical space of over 1060 conceivable compounds can be filtered to a manageable number that can be synthesized, purchased, and tested.
Drug designDrug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it.
Terrestrial TimeTerrestrial Time (TT) is a modern astronomical time standard defined by the International Astronomical Union, primarily for time-measurements of astronomical observations made from the surface of Earth. For example, the Astronomical Almanac uses TT for its tables of positions (ephemerides) of the Sun, Moon and planets as seen from Earth. In this role, TT continues Terrestrial Dynamical Time (TDT or TD), which succeeded ephemeris time (ET). TT shares the original purpose for which ET was designed, to be free of the irregularities in the rotation of Earth.
Marine protected areaMarine protected areas (MPA) are protected areas of seas, oceans, estuaries or in the US, the Great Lakes. These marine areas can come in many forms ranging from wildlife refuges to research facilities. MPAs restrict human activity for a conservation purpose, typically to protect natural or cultural resources. Such marine resources are protected by local, state, territorial, native, regional, national, or international authorities and differ substantially among and between nations.
Capacity managementCapacity management's goal is to ensure that information technology resources are sufficient to meet upcoming business requirements cost-effectively. One common interpretation of capacity management is described in the ITIL framework. ITIL version 3 views capacity management as comprising three sub-processes: business capacity management, service capacity management, and component capacity management. As the usage of IT services change and functionality evolves, the amount of central processing units (CPUs), memory and storage to a physical or virtual server etc.
FCAPSFCAPS is the ISO Telecommunications Management Network model and framework for network management. FCAPS is an acronym for fault, configuration, accounting, performance, security, the management categories into which the ISO model defines network management tasks. In non-billing organizations accounting is sometimes replaced with administration. The ISO, under the direction of the OSI group, has created a network management model as the primary means for understanding the major functions of network management systems.
