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Corneal epithelial stem cells and their niche at a glance

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Sutureless ocular surface reconstruction

Basile Salmon

Corneal diseases account for eight million blind people worldwide, making up to 10% of all causes of blindness. As 80% of the information is collected by our senses, blindness is a very invalidating condition which lowers greatly patients’ quality of life. ...

2010

Essential Role for Pbx1 in Corneal Morphogenesis

PURPOSE. The Pbx TALE (three-amino-acid loop extension) homeodomain proteins interact with class 1 Hox proteins, which are master regulators of cell fate decisions. This study was performed to elucidate the role of the Pbx1 TALE protein in the corneal epit ...

2010

Modeling the cornea: an architectural approach

Julien Graber

Nowadays the mechanism regulating the corneal epithelium renewal still remains unclear. Until now it was thought to be the fact of stem cells distributed in the limbus, generating TA cells migrating towards the central cornea and responsible for its renewa ...

2009

Artificial stem cell niches

Matthias Lütolf

Stem cells are characterized by their dual ability to reproduce themselves (self-renew) and specialize (differentiate), yielding essentially unlimited numbers of daughter cells that can maintain and regenerate tissues. In contrast to their embryonic counte ...

2009

Muscle stem cell's in vitro bipolar niche

Adrien de Tonnac

In the domain of regenerative medicine research there are many fronts aimed at increasing our understanding of induced pluripotent, embryonic and adult stem cells. Recently a new front has appeared, stem cell niches, the microenvironment that is a crucial ...

2009

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

Freddy Radtke, Ivan Stamenkovic

Purpose. The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro w ...

2009

Bioengineering stem cell niches in 2D and 3D

Nora Leonardi

Muscle degenerative disorders, such as Duchenne muscular dystrophy, have a profound impact on the quality of life and survival of patients. Transplantation of myoblasts to restore muscle function has been discouraging since these cells die and don't migrat ...

2009

Asymmetric distribution of epidermal growth factor receptor directs the fate of normal and cancer keratinocytes in vitro

Nathan Quentin Faivre

Cancer cells are unequal in a tumor mass and in established cultures. This is attributable to cancer stem cells with the unique ability to self-renew and to generate differentiating progeny. This ability is controlled at the level of asymmetric division by ...

2009

Oligopotent stem cells are distributed throughout the mammalian ocular surface

Yann Barrandon, Ariane Rochat, Georges Abou Jaoudé

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty- five million individuals worldwide are bilaterally blind and another 135 million have severely impaired vision in both eyes because of loss of corneal trans ...

2008

Understanding engraftment of cultured epidermal stem cells

Nicolas Grasset

The epidermis and its appendages protect our body from environmental hazards. Cells generated in the basal layer continuously replace the terminally differentiated keratinocytes that are shed off the epidermal surface. Long-term renewal depends on specific ...

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