Publication
Regulation of Mammalian Physiology by interconnected Circadian and Feeding Rhythms
Related publications (76)
Statistical physics of periodic biological processes
Earth rotation around its axis imposes a 24-hour rhythmicity to all life on the planet.Rather than passively responding to these periodic changes, nature has given us an internal timekeeper, the circadian clock, to anticipate to our advantage the fluctuati ...
EPFL2023Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior
Cédric Gobet, Sylviane Métairon, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger
The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circad ...
AMER ASSOC ADVANCEMENT SCIENCE2023Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
Felix Naef, Cédric Gobet, Lorenzo Talamanca
The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data from the Genotype-Tissue Expression (GTEx) project with an a ...
AMER ASSOC ADVANCEMENT SCIENCE2023Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling
Felix Naef, Nicholas Edward Phillips
Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in ...
CELL PRESS2023The circadian clock time tunes axonal regeneration
Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and-independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain ...
Cambridge2023Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver
Felix Naef, Cédric Gobet, Benjamin Dieter Weger, Clémence Yumie Syloun Hurni
In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of ...
PUBLIC LIBRARY SCIENCE2022VELUX Build for Life
In this video, Prof. Marilyne Andersen discusses the many benefits, challenges, promises and ongoing research on daylighting as an essential part of our daily life. The podcast addresses questions of design, comfort, resource efficiency and health by divin ...
2022Space-time logic of liver gene expression at sub-lobular scale
Felix Naef, Clémence Yumie Syloun Hurni, Colas Noé Droin
The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive tempo ...
NATURE RESEARCH2021Circadian dynamics of RNA localisation in the mammalian liver
Gene expression in eukaryotes is a complex multi-step process. It starts in the nucleus with transcription, the synthesis of a mRNA copy from a DNA template. While in the nucleus, the RNA transcript is subject to multiple co- and post-transcriptional modif ...
EPFL2021Comment on "Circadian rhythms in the absence of the clock gene Bmal1"
Ray et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this gen ...
2021