Publication

Force transmission during adhesion-independent migration

Related publications (36)

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Cell shape-dependent early responses of fibroblasts to cyclic strain

Jürgen Brugger, Mattia Marelli

Randomly spread fibroblasts on fibronectin-coated elastomeric membranes respond to cyclic strain by a varying degree of focal adhesion assembly and actin reorganization. We speculated that the individual shape of the cells, which is linked to cytoskeletal ...

Elsevier2013

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

Stefan Kobel

Since stem cells have the unique ability to produce more of themselves (i.e. to "self-renew") and to generate specialized tissue cells, they are an ideal source of cells for regenerative medicine and in vitro tissue models. In order to fully exploit this p ...

EPFL2012

Numerically bridging lamellipodial and filopodial activity during cell spreading reveals a potentially novel trigger of focal adhesion maturation

Benoît Vianay

We present a novel approach to modeling cell spreading, and use it to reveal a potentially central mechanism regulating focal adhesion maturation in various cell phenotypes. Actin bundles that span neighboring focal complexes at the lamellipodium-lamellum ...

2012

Ability to migrate is a fundamental property of all animal cells. Cell migration underlies such important physiological and pathological processes as embryonic development, immune response, tissue regeneration and cancer metastasis. As cell migration invol ...

EPFL2011

, ,

Cultured fibroblasts adhere to extracellular substrates by means of cell-matrix adhesions that are assembled in a hierarchical way, thereby gaining in protein complexity and size. Here we asked how restricting the size of cell-matrix adhesions affects cell ...

Public Library of Science2011

, ,

Engineered artificial microenvironments hold enormous potential as models to study developmental, physiological, pathological, and regenerative processes under highly defined conditions. Such platforms aim at bridging the gap between traditional in vitro 2 ...

2011

Cartilage tissue engineering aims to develop a material that can be implanted with cells to repair damage in articular cartilage. The extracellular matrix is known to play a key role in regulating stem cell behaviour via cell-matrix interactions and integr ...

2011

3D collagen cultures under well-defined dynamic strain: A novel strain device with a porous elastomeric support

Melody Swartz, Alice Anna Tomei, Federica Boschetti

The field of mechanobiology has grown tremendously in the past few decades, and it is now well accepted that dynamic stresses and strains can impact cell and tissue organization, cell-cell and cell-matrix communication, matrix remodeling, cell proliferatio ...

Wiley-Blackwell2009

Tissue engineering of the bladder

Catharina Adelöw

Stem cell use in bladder tissue engineering is a recently addressed area of investigation that has generated excitement as a novel way to restore and regenerate lost or damaged urinary bladder tissue. The remodelling of smooth muscle plays a significant ro ...

EPFL2009

Probing the differential adhesion hypothesis in the mammary gland using different bioengineered cell culture substrata

Léa Chanson

During tissue development, cells are able to form different layers and to self organize. At the moment, there are two principal hypotheses that try to explain cell sorting. The so called differential adhesion hypothesis (DAH) posits that cells organize acc ...

2009