Publication
Wnt-regulated dynamics of positional information in zebrafish somitogenesis
Related publications (52)
ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm
The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in induction and patterning of the ventral forebrain. Currently little is known about how Shh is regulated in prechordal tissue. Here we s ...
Company of Biologists2015Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
Cathrin Brisken, Jacques Rougemont, Ayyakkannu Ayyanan, Marian Caikovski, Renuga Devi Rajaram, Duje Buric
Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regene ...
Wiley-Blackwell2015Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Olivier Martin, Gerardo Turcatti, Nicolas Jean Philippe Guex, Marc Chambon
The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...
Nature Publishing Group2015Tbx6, Mesp-b and ripply1 regulate the onset of skeletal myogenesis in zebrafish
During embryonic development, the paraxial mesoderm becomes segmented into somites, within which proliferative muscle progenitors and muscle fibers establish the skeletal musculature. Here, we demonstrate that a gene network previously implicated in somite ...
2015The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer
Aberrantly active Wnt signaling is the hallmark driver of colorectal cancer (CRC). Bcl9/9l proteins are components of the main transcriptional activation complex of canonical Wnt signaling and interact with beta-catenin via a highly conserved homology doma ...
EPFL2014Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development
Michel Aguet, Andreas Eduard Moor
Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between beta-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the ...
Cold Spring Harbor Laboratory Press2014The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription
Pygopus has been discovered as a fundamental Wnt signaling component in Drosophila. The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2. They serve as context-dependent beta-catenin coactivators, with Pygo2 playing the more important role. All P ...
Company Of Biologists Ltd2013Anthrax toxin receptor 2a controls mitotic spindle positioning
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Oriented mitosis is essential during tissue morphogenesis. The Wnt/planar cell polarity (Wnt/PCP) pathway orients mitosis in a number of developmental systems, including dorsal epiblast cell divisions along the animal-vegetal (A-V) axis during zebrafish ga ...
Nature Publishing Group2013Bigh3 Is Upregulated in Regenerating Zebrafish Fin
Zebrafish is a good model for studying regeneration because of the rapidity with which it occurs. Better understanding of this process may lead in the future to improvement of the regenerating capacity of humans. Signaling factors are the second largest ca ...
Mary Ann Liebert Inc2013Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk
Abstract The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-in ...
Nature Publishing Group2013