Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization
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The development of more effective approaches for controlling dexterous hand prostheses is an important area of research currently addressed by several groups with the aim of improving the quality of life of amputees. It is particularly important to establi ...
Experience leaves a trace in the nervous system through plasticity. However, the exact meaning of the mnesic trace is poorly defined in current literature. This article provides a historical review of the term trace in neuroscience and psychoanalysis liter ...
Triggered assistance has been shown to be a successful robotic strategy for provoking motor plasticity, probably because it requires neurologic patients’ active participation to initiate a movement involving their impaired limb. Triggered assistance, howev ...
Individuals with severe neurologic injuries often cannot participate in robotic rehabilitation because they do not retain sufficient residual motor control to initiate the robotic assistance. In these situations, brain- and body-computer interfaces have em ...
Background: The restoration of complex hand functions by creating a novel bidirectional link between the nervous system and a dexterous hand prosthesis is currently pursued by several research groups. This connection must be fast, intuitive, with a high su ...
The treatment of disorders of the nervous system poses a major clinical challenge. Development of neuromodulation (i.e., interfacing electronics to nervous tissue to modulate its function) has provided patients with neuronal-related deficits a new tool to ...
Replacing a missing upper limb with a functional one is an ancient need and desire. The need for a versatile prosthetic limb with intuitive motor control and realistic sensory feedback is huge and its development is absolutely necessary for the near future ...
Interspecies variation in sensitivity to synthetic chemicals can be orders of magnitude large. Species traits causing the variation can be related to toxicokinetics (uptake, distribution, biotransformation, elimination) or toxicodynamics (interaction with ...
SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism, the re ...
Accurate methods to measure autophagic activity in vivo in neurons are not available, and most of the studies are based on correlative and static measurements of autophagy markers, leading to conflicting interpretations. Autophagy is an essential homeostat ...
