Method for nmr spectrometry or mri measurement using dissolution dynamic nuclear polarization (dnp) with scavenging of free radicals

Geoffrey Bodenhausen, Sami Jannin, Pascal Miéville
2011
Patent

Abstract

PROBLEM TO BE SOLVED: To provide a method for extending longitudinal relaxation time and transverse relaxation time in nuclear magnetic resonance (NMR), while removing free radicals from hyperpolarized solution. SOLUTION: A method for preparing samples for magnetic resonance measurement by using dissolution dynamic nuclear polarization-based hyperpolarization, includes the step (1.1) to prepare frozen beads of a first kind containing paramagnetic substances in addition to a solute under examination; the step (2.1) to insert the frozen beads into a polarization magnet; the step (3.1) to create a higher polarization state of the nuclei in a magnetic field; the step (4.1) to heat the sample up to room temperature, the step (5.1) to transfer samples into MR magnet; and the step (6.1) to perform MR measurement. Further, additional steps are included, the step (1.2) to prepare frozen beads of a second kind containing a reduction agent, and the step (2.2) to insert the frozen beads of a second kind together with the frozen beads of the first kind into the polarization magnet. ;COPYRIGHT: (C)2011,JPO&INPIT

Official source

https://infoscience.epfl.ch/record/229010?ln=en

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