Vascular endothelial growth factorVascular endothelial growth factor (VEGF, vɛdʒ'ɛf), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).
Anoxic eventOceanic anoxic events or anoxic events (anoxia conditions) describe periods wherein large expanses of Earth's oceans were depleted of dissolved oxygen (O2), creating toxic, euxinic (anoxic and sulfidic) waters. Although anoxic events have not happened for millions of years, the geologic record shows that they happened many times in the past. Anoxic events coincided with several mass extinctions and may have contributed to them. These mass extinctions include some that geobiologists use as time markers in biostratigraphic dating.
Lau eventThe Lau event was the last of three relatively minor mass extinctions (the Ireviken, Mulde, and Lau events) during the Silurian period. It had a major effect on the conodont fauna, but barely scathed the graptolites, though they suffered an extinction very shortly thereafter termed the Kozlowskii event that some authors have suggested was coeval with the Lau event and only appears asynchronous due to taphonomic reasons.
Cell adhesionCell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released by cells into spaces between them. Cells adhesion occurs from the interactions between cell-adhesion molecules (CAMs), transmembrane proteins located on the cell surface.
Permian–Triassic extinction eventThe Permian–Triassic (P–T, P–Tr) extinction event (PTME), also known as the Late Permian extinction event, the Latest Permian extinction event, the End-Permian extinction event, and colloquially as the Great Dying, forms the boundary between the Permian and Triassic geologic periods, and with them the Paleozoic and Mesozoic eras respectively, approximately 251.9 million years ago. As the largest of the "Big Five" mass extinctions of the Phanerozoic, it is the Earth's most severe known extinction event, with the extinction of 57% of biological families, 83% of genera, 81% of marine species and 70% of terrestrial vertebrate species.
ExperimentAn experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies.
Quasi-experimentA quasi-experiment is an empirical interventional study used to estimate the causal impact of an intervention on target population without random assignment. Quasi-experimental research shares similarities with the traditional experimental design or randomized controlled trial, but it specifically lacks the element of random assignment to treatment or control. Instead, quasi-experimental designs typically allow the researcher to control the assignment to the treatment condition, but using some criterion other than random assignment (e.
Milgram experimentThe Milgram experiment(s) on obedience to authority figures were a series of social psychology experiments conducted by Yale University psychologist Stanley Milgram. They measured the willingness of study participants, 40 men in the age range of 20 to 50 from a diverse range of occupations with varying levels of education, to obey an authority figure who instructed them to perform acts conflicting with their personal conscience. Participants were led to believe that they were assisting an unrelated experiment, in which they had to administer electric shocks to a "learner".
LamininLaminins are a family of glycoproteins of the extracellular matrix of all animals. They are major components of the basal lamina (one of the layers of the basement membrane), the protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa).
Natural killer cellNatural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system that belong to the rapidly expanding family of known innate lymphoid cells (ILC) and represent 5–20% of all circulating lymphocytes in humans. The role of NK cells is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response. NK cells provide rapid responses to virus-infected cell and other intracellular pathogens acting at around 3 days after infection, and respond to tumor formation.
