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Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats
Related publications (41)
Probiotics and gut microbiome-Prospects and challenges in remediating heavy metal toxicity
Edgard Gnansounou, Ranjna Sirohi
The gut microbiome, often referred to as "super organ", comprises up to a hundred trillion microorganisms, and the species diversity may vary from person to person. They perform a decisive role in diverse biological functions related to metabolism, immunit ...
ELSEVIER2021Metabolic rescue of muscle and muscle stem cells in muscle disease
Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...
EPFL2020Biogeography of microbial bile acid transformations along the murine gut
Rizlan Bernier-Latmani, Laure Menin, Solenne Anne Marie Marion, Lyne Desharnais
Bile acids, which are synthesized from cholesterol by the liver, are chemically transformed along the intestinal tract by the gut microbiota, and the products of these transformations signal through host receptors, affecting overall host health. These tran ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids
The gut microbiome has been linked to fear extinction learning in animal models. Here, we aimed to explore the gut microbiome and memory domains according to obesity status. A specific microbiome profile associated with short-term memory, working memory, a ...
CELL PRESS2020Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut
Bile acids (BAs) are small molecules synthesized by the host and chemically modified by the microorganisms inhabiting the intestinal tract. The microbial transformation of BAs in the gut is critical to BA-mediated signaling as it modifies their amount and ...
EPFL2020Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine
Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Alexis Rapin, Luc Xavier Marie Lebon, Audrey Geneviève Chuat
Increasing evidence suggests that intestinal helminth infection can alter intestinal microbial communities with important impacts on the mammalian host. However, all of the studies to date utilize different techniques to study the microbiome and access dif ...
2020Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice
Alzheimer's disease (AD) affects an estimated 5.8 million Americans, and advanced age is the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting intestinal microbiota in AD animal models reduces amyloid-beta (A beta ...
Springer2019The gut microbiota influences skeletal muscle mass and function in mice
Johan Auwerx, Hongbo Zhang, Walter Wahli
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...
AMER ASSOC ADVANCEMENT SCIENCE2019Cross-species functional modules link proteostasis to human normal aging
Johan Auwerx, Hao Li, Vincenzo Sorrentino, Andrea Komljenovic
The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...
PUBLIC LIBRARY SCIENCE2019A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals
Jacques Fellay, Christian Hammer, Flavia Aurelia Shoko Hodel, Petar Scepanovic
Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...
2019