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Cyclic peptide therapeutics: past, present and future

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Cyclic Peptides for Drug Development

Christian Heinis, Xinjian Ji, Alexander Lund Nielsen

Cyclic peptides combine a number of favorable properties that make them attractive for drug development. Today, more than 40 therapeutics based on cyclic peptides are in use, and new, powerful technologies for their development suggest that this number cou ...

2024

Synthetic Studies toward Amanita Phalloides Toxins

Philipp Georg Werner Seeberger

Amatoxins are ribosomally synthesized and post-translationally modified bicyclic octapeptides biosynthesized by the deadly basidiomycete fungus Amanita phalloides. Amongst this group, alpha-amanitin is the most widely known toxin and is currently under inv ...

EPFL2020

The shaping effects of innovation and technology: from micro business model evolution to macro environment sustainability

Qinli Lu

Innovation is a prerequisite guarantee for the development of a country in this new era. It is an important driver not just for corporate growth but also for national social and economic transformation. Considering the strategic supporting role of innovati ...

EPFL2020

Challenges for biophysical modeling of microstructure

Ileana Ozana Jelescu

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifyi ...

2020

Food Action: A Pilot Program for more Sustainable Food Habits

Food is a critical global resource that impacts all 17 of the UN Sustainable Development Goals, and a huge contributor to both problems (climate, environment, health) and solutions. The Food Action project engaged 5 countries in developing and testing a pr ...

Paul Scherrer Institute, World Resources Forum2019

Lean synthesis and application to lower-limb exoskeletons

Tristan Hubert Vouga

Mobility impairments are the most prevalent of all disabilities, affecting the life of nearly one in 20 individuals in developed countries. In the most severe cases, they can have dramatic consequences for the social, mental and physical well-being of thos ...

EPFL2019

Design and development of a display device for Lippmann plates

Kjell Sverre Høyvik Bergum

Semester project to design and develop a display device for use at Musée de l’Elysée to display Lippmann plates. Display platform and light fixtures designed to obtain the full spectrum of Lippmann plates. ...

2018

Validation strategies for the interpretation of microstructure imaging using diffusion MRI

Giorgio Innocenti, Tim Bjørn Dyrby

Extracting microanatomical information beyond the image resolution of MRI would provide valuable tools for diagnostics and neuroscientific research. A number of mathematical models already suggest microstructural interpretations of diffusion MRI (dMRI) dat ...

2018

Drugs Based on de novo-developed Peptides are Coming of Age

Christian Heinis

Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides. Not every desired target has a naturally occurring bioacti ...

SWISS CHEMICAL SOC2018

A Roadmap for the Development of Precision Medicine

Marie-Valentine Renée Agnès Florin, Gérard Escher

The purpose of the roadmap proposed by IRGC is to recommend a structured process that organisations can follow in their transition towards the development of precision medicine. The process is adaptable, and each organisation should further develop it to a ...

International Risk Governance Center (IRGC)2017