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Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex

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The In-Silico Neocortical Microcircuit

Michael Reimann

The neocortex is one of the most important brain regions, occupying more than 80% of the brain volume in mammals and contributing massively to its capability of perceiving and interpreting then environment. While it has been extensively studied, it is stil ...

EPFL2014

A new Mathematical Framework to Understand Single Neuron Computations

Skander Mensi

An important feature of the nervous system is its ability to adapt to new stimuli. This adaptation allows for optimal encoding of the incoming information by dynamically changing the coding strategy based upon the incoming inputs to the neuron. At the leve ...

EPFL2014

Growth of Secondary Dendrite Arms of Fe C Alloy during Transient Directional Solidification by Phase-field Method

Jonathan Dantzig, Yu Xie

Due to the variations in the local solidification conditions in typical industrial casting processes, dendrites grow under transient rather than steady-state conditions. In this study, the phase-field method was used to study the evolution of secondary den ...

Iron Steel Inst Japan Keidanren Kaikan2014

The Green's function formalism as a bridge between single- and multi-compartmental modeling

Willem Anna Mark Wybo, Benjamin Torben-Nielsen

Neurons are spatially extended structures that receive and process inputs on their dendrites. It is generally accepted that neuronal computations arise from the active integration of synaptic inputs along a dendrite between the input location and the locat ...

Springer Berlin Heidelberg2013

Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

Wulfram Gerstner

Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol-consisting of pair ...

Elife Sciences Publications Ltd2013

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

Carl Petersen, Sylvain Crochet

Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory glutamatergic and inhibitory GABAergic inputs. New optical, electrophysiological, and genetic methods allow detailed in vivo investigation of the superficia ...

Cell Press2013

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Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an uncharacterized protein belonging to the P-5-type ATPase subfamily that is predicted to regulate t ...

Oxford University Press2012

Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms

Wulfram Gerstner, Carl Petersen, Richard Naud, Skander Mensi, Christian Antonio Pozzorini, Michael Avermann

Mensi S, Naud R, Pozzorini C, Avermann M, Petersen CCH, Gerstner W. Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms. J Neurophysiol 107: 1756-1775, 2012. First published December 7, 2011; do ...

American Physiological Society2012

How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-a ...

2012

Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in ...

Nature Publishing Group2012