Efficient inference for genetic association studies with multiple outcomes
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This thesis consists of five papers published in peer-reviewed journals, two of which focus on method development of time-serial inference, represented by publications in methodology journals, and three others that describe collaborative data applications ...
Humans are comparison machines: comparing and choosing an item among a set of alternatives (such as objects or concepts) is arguably one of the most natural ways for us to express our preferences and opinions. In many applications, the analysis of data con ...
The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine.The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...
Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...
Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...
The emergence of motorcycle taxis as a mode of urban transport in Africa can be seen as a bottom-up response to the larger problem of a demand that is not sufficiently met by public services. Transcending the debates regarding the relevance of this solutio ...
Genetic association studies have become increasingly important in understanding the molecular bases of complex human traits. The specific analysis of intermediate molecular traits, via quantitative trait locus (QTL) studies, has recently received much atte ...
Increasing demand for new infrastructure and ageing of existing infrastructure has made management of infrastructure a key challenge of this century. Replacement of all ageing civil infrastructure is economically and environmentally unsustainable. Civil in ...
Natural populations present an abundant genetic variability. Like mutation or natural se- lection, dierent processes are at stake to generate this variability. Population genetics is a topic that emerged in the late 40's, thanks mainly to the biologists Fi ...
Genome-wide association (GWA) studies aim to dissect the relationship between genotype and phenotype. So far, the focus has been on nuclear genetic determinants as variation in the mitochondrial genome is often low in the study cohorts. Despite this observ ...
