Publication
Versatile palladium-catalyzed double carbonylation of aryl bromides
Related publications (12)
Algorithms and flowchart for the design of synthetic biochemical networks
New drugs are needed to assure effective therapies for previously untreated diseases, emerging diseases, and personalized medicine, but the process of drug development is complex, costly, and time-consuming. This is especially problematic considering that ...
EPFL2020An In Situ Surface-Enhanced Infrared Absorption Spectroscopy Study of Electrochemical CO2 Reduction: Selectivity Dependence on Surface C-Bound and O-Bound Reaction Intermediates
Nicola Marzari, Oliviero Andreussi, Francesco Nattino
The CO2 electroreduction reaction (CO2RR) is a promising avenue to convert greenhouse gases into high-value fuels and chemicals, in addition to being an attractive method for storing intermittent renewable energy. Although polycrystalline Cu surfaces have ...
AMER CHEMICAL SOC2019Mechanistic Study of the N-Formylation of Amines with Carbon Dioxide and Hydrosilanes
Paul Joseph Dyson, Gabor Laurenczy, Martin Hulla
N-formylation of amines with CO2 and hydrosilane reducing agents proceeds via fast and complex chemical equilibria, which hinder easy analysis of the reaction pathways. In situ reaction monitoring and kinetic studies reveal that three proposed pathways, vi ...
2018Regiodivergent Cyclobutanone Cleavage: Switching Selectivity with Different Lewis Acids
Nicolai Cramer, Laetitia Marie Mélanie Souillart
The exploitation of strain release in small rings as driving force to enable complex transformations is a powerful synthetic tool. Among them, cyclobutanones are particularly versatile substrates that can be elaborated in a wide variety of structurally div ...
Wiley-Blackwell2015Towards a kinetic model of the phospholipids biosynthesis of the yeast Saccharomyces cerevisiae
Vassily Hatzimanikatis, Meriç Ataman, Georgios Savoglidis, Iro Oikonomidi
Lipids, as vital eukaryotic cellular components, play a major role in cell, tissue and organ physiology. Alterations of lipid enzymes and metabolic pathways are related to many human diseases, such as cancer, diabetes and neurodegenerative diseases. In thi ...
2014The electro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway
Duncan Thomas Lindsay Alexander
A new study is presented on the electro-deoxidation of porous TiO2 precursors in molten calcium chlo- ride electrolytes. It is shown that by reducing precursor open porosity from standard values of ≥25% to ∼11–12%, such that there is insufficient free volu ...
Elsevier2011Unraveling the Catalytic Pathway of Metalloenzyme Farnesyltransferase through QM/MM Computation
The protein farnesyltransferase (FTase) is a Zn2+-metalloenzyme that catalyzes the farnesylation reaction, i.e., the transfer of the 15-carbon atom farnesyl group from farnesyl diphosphate (FPP) to a specific cysteine of protein substrates. Oncogenic Ras p ...
2009Analysis of free energy change and thermodynamic feasibility in a genome scale metabolic model
With the sequencing and annotation of the entire genomes of numerous microorganisms has come the advent of the genome scale metabolic models such as the iJR904 model of E. coli from Palsson and coworkers. Metabolic flux anal. (MFA) is widely employed to ge ...
2005QM and QM/MM studies of the phosphoryl transfer reaction catalyzed by a cyclin-dependent kinase (CDKs)
The regulation of the eukaryotic cell cycle depends on the action of several related Ser/Thr protein kinases called cyclin-dependent kinases (CDKs), which are transiently activated at specific stages of the cycle, and which are also very promising targets ...
2004Unidirectional steady state rates of central metabolism enzymes measured simultaneously in a living plant tissue
The unidirectional steady state reaction rates of several enzymes and metabolic fluxes of distinct processes were measured simultaneously in hypoxic maize root tips using two-dimensional phosphorus NMR exchange spectroscopy. A single spectrum monitors ATP ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC1998