Publication
Coherent Imaging of Cellular Dynamics
Related concepts (35)
Progeroid syndromes
Progeroid syndromes (PS) are a group of rare genetic disorders that mimic physiological aging, making affected individuals appear to be older than they are. The term progeroid syndrome does not necessarily imply progeria (Hutchinson–Gilford progeria syndrome), which is a specific type of progeroid syndrome. Progeroid means "resembling premature aging," a definition that can apply to a broad range of diseases. Familial Alzheimer's disease and familial Parkinson's disease are two well-known accelerated-aging diseases that are more frequent in older individuals.
Immunofluorescence
Immunofluorescence is a technique used for light microscopy with a fluorescence microscope and is used primarily on biological samples. This technique uses the specificity of antibodies to their antigen to target fluorescent dyes to specific biomolecule targets within a cell, and therefore allows visualization of the distribution of the target molecule through the sample. The specific region an antibody recognizes on an antigen is called an epitope.
Modifiable temporal unit problem
The Modified Temporal Unit Problem (MTUP) is a source of statistical bias that occurs in time series and spatial analysis when using temporal data that has been aggregated into temporal units. In such cases, choosing a temporal unit (e.g., days, months, years) can affect the analysis results and lead to inconsistencies or errors in statistical hypothesis testing. The MTUP is closely related to the modifiable areal unit problem or MAUP, in that they both relate to the scale of analysis and the issue of choosing an appropriate analysis.
Modifiable areal unit problem
NOTOC The modifiable areal unit problem (MAUP) is a source of statistical bias that can significantly impact the results of statistical hypothesis tests. MAUP affects results when point-based measures of spatial phenomena are aggregated into spatial partitions or areal units (such as regions or districts) as in, for example, population density or illness rates. The resulting summary values (e.g., totals, rates, proportions, densities) are influenced by both the shape and scale of the aggregation unit.
Xeroderma pigmentosum
Xeroderma pigmentosum (XP) is a genetic disorder in which there is a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light. Symptoms may include a severe sunburn after only a few minutes in the sun, freckling in sun-exposed areas, dry skin and changes in skin pigmentation. Nervous system problems, such as hearing loss, poor coordination, loss of intellectual function and seizures, may also occur. Complications include a high risk of skin cancer, with about half having skin cancer by age 10 without preventative efforts, and cataracts.