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Thermal-responsive biodegradable composite membrane for drug delivery application
Related concepts (33)
Route of administration
In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration. Routes can also be classified based on where the target of action is. Action may be topical (local), enteral (system-wide effect, but delivered through the gastrointestinal tract), or parenteral (systemic action, but delivered by routes other than the GI tract).
Targeted drug delivery
Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue.
Wild silk
Wild silks have been known and used in many countries from early times, although the scale of production is far smaller than that from cultivated silkworms. Silk cocoons and nests often resemble paper or cloth, and their use has arisen independently in many societies. Silk taken from various species has been used since ancient times, either in its natural state or after some form of preparation. Spider webs were used as a wound dressing in ancient Greece and Rome, and as a base for painting from the 16th century.
Self-assembly of nanoparticles
Nanoparticles are classified as having at least one of three dimensions be in the range of 1-100 nm. The small size of nanoparticles allows them to have unique characteristics which may not be possible on the macro-scale. Self-assembly is the spontaneous organization of smaller subunits to form larger, well-organized patterns. For nanoparticles, this spontaneous assembly is a consequence of interactions between the particles aimed at achieving a thermodynamic equilibrium and reducing the system’s free energy.
Electric heating
Electric heating is a process in which electrical energy is converted directly to heat energy. Common applications include space heating, cooking, water heating and industrial processes. An electric heater is an electrical device that converts an electric current into heat. The heating element inside every electric heater is an electrical resistor, and works on the principle of Joule heating: an electric current passing through a resistor will convert that electrical energy into heat energy.
Oral administration
Oral administration is a route of administration whereby a substance is taken through the mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administration can be easier and less painful than other routes of administration, such as injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream.
Natural fiber
Natural fibers or natural fibres (see spelling differences) are fibers that are produced by geological processes, or from the bodies of plants or animals. They can be used as a component of composite materials, where the orientation of fibers impacts the properties. Natural fibers can also be matted into sheets to make paper or felt. The earliest evidence of humans using fibers is the discovery of wool and dyed flax fibers found in a prehistoric cave in the Republic of Georgia that date back to 36,000 BP.
Assam silk
Assam silk denotes the three major types of indigenous wild silks produced in Assam—golden muga, white pat and warm eri silk. The Assam silk industry, now centered in Sualkuchi, is a labor-intensive industry. Assam was well known for the production of high quality silk since ancient times. The craft of weaving goes along with the production of silk. It grew to such sophistication in Assam that it was known all over India and abroad.
Fibroin
Fibroin is an insoluble protein present in silk produced by numerous insects, such as the larvae of Bombyx mori, and other moth genera such as Antheraea, Cricula, Samia and Gonometa. Silk in its raw state consists of two main proteins, sericin and fibroin, with a glue-like layer of sericin coating two singular filaments of fibroin called brins. Silk fibroin is considered a β-keratin related to proteins that form hair, skin, nails and connective tissues. The silk worm produces fibroin with three chains, the light, heavy, and the glycoprotein P25.
Sericin
Sericin is a protein created by Bombyx mori (silkworms) in the production of silk. Silk is a fibre produced by the silkworm in production of its cocoon. It consists mainly of two proteins, fibroin and sericin. Silk consists of 70–80% fibroin and 20–30% sericin; fibroin being the structural center of the silk, and sericin being the gum coating the fibres and allowing them to stick to each other. Sericin is composed of 18 different amino acids, of which 32% is serine.