Publications related to Reprogramming the B1 Domain of Streptococcal Protein G (GB1)

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Lijing Xin, Daniel Wenz, Mark Stephan Widmaier, Songi Lim

A new and efficient magnetisation transfer P-31 magnetic resonance fingerprinting (MT-P-31-MRF) approach is introduced to measure the creatine kinase metabolic rate kCK

{k}_{\mathrm{CK}}

between phosphocreatine (PCr) and adenosine triphosphate (ATP) i ...

WILEY2023

Beyond worst-case analysis, with or without predictions

Andreas Maggiori

In this thesis we design online combinatorial optimization algorithms for beyond worst-case analysis settings.In the first part, we discuss the online matching problem and prove that, in the edge arrival model, no online algorithm can achieve a competitive ...

EPFL2023

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Maria Letizia Merlini

In the last years, it has been demonstrated a link between the overload of metal ions inside nervous system cells and the onset of severe neurodegenerative diseases. This prompted the investigation of the structural and functional properties of transporter ...

EPFL2022

Computational tools and resources for designing new pathways to small molecules

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The metabolic engineering community relies on computational methods for pathway design to produce important small molecules in microbial hosts. Metabolic network databases are continuously curated and updated with known and novel reactions that expand the ...

CURRENT BIOLOGY LTD2022

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Bruno Emanuel Ferreira De Sousa Correia, Anthony Marchand, Alexandra Krina Van Hall-Beauvais

Protein–protein interactions (PPIs) govern numerous cellular functions in terms of signaling, transport, defense and many others. Designing novel PPIs poses a fundamental challenge to our understanding of molecular interactions. The capability to robustly ...

2022

Policy-based Exploration of Equilibrium Representations (PEER): A topology grammar for generative conceptual structural design

Ioannis Mirtsopoulos

Design exploration is a creative process that consists of the incremental generation of design candidates. Supported by digital means or not, the process handles the ill-structured nature of design and allows creativity to flourish through diversity of des ...

EPFL2022

Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis

Patrick Daniel Barth, Mahdi Hijazi, Aurélien Laurent Jean-Charles Oggier, Ana Paola Rico Villarreal, Robert Everett Jefferson, Andreas Füglistaler

Engineering biosensors that sensitively recognize specific biomolecules and trigger functional cellular responses is a holy grail of diagnostics and synthetic cell biology. Biosensor design approaches have mostly focused on binding structurally well-define ...

bioRxiv2022

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Andreas Scheck

Proteins are fundamental components in biological systems and crucial for a variety of biological functions. Over the last decades, significant progress in structural biology has facilitated the study of proteins and their interactions with molecular partn ...

EPFL2021

Computational Analysis and Design of Structurally Stable Assemblies with Rigid Parts

An assembly refers to a collection of parts joined together to achieve a specific form and/or functionality. Assemblies make it possible to fabricate large and complex objects with several small and simple parts. Such parts can be assembled and disassemble ...

EPFL2021

State of the Art on Computational Design of Assemblies with Rigid Parts

Mark Pauly, Peng Song

An assembly refers to a collection of parts joined together to achieve a specific form and/or functionality. Designing assemblies is a non-trivial task as a slight local modification on a part's geometry or its joining method could have a global impact on ...

WILEY2021

Reprogramming the B1 Domain of Streptococcal Protein G (GB1)

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Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Beyond worst-case analysis, with or without predictions

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Computational tools and resources for designing new pathways to small molecules

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Policy-based Exploration of Equilibrium Representations (PEER): A topology grammar for generative conceptual structural design

Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Computational Analysis and Design of Structurally Stable Assemblies with Rigid Parts

State of the Art on Computational Design of Assemblies with Rigid Parts

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Beyond worst-case analysis, with or without predictions

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Computational tools and resources for designing new pathways to small molecules

Policy-based Exploration of Equilibrium Representations (PEER): A topology grammar for generative conceptual structural design

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis

Computational Analysis and Design of Structurally Stable Assemblies with Rigid Parts

State of the Art on Computational Design of Assemblies with Rigid Parts