Publication
Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression
Related publications (32)
Kinetic Analysis of Transcriptional and Post-Transcriptional Processes During Circadian Cycles
Every morning the sun rises, flooding the earth with its light and heat and every night it disappears leaving the Earth in the darkness of the night. Organisms living on this planet have adapted to this solar rhythm and have spread their activities through ...
EPFL2013Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK-BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accessory feedb ...
2012Deletion of CREB-Regulated Transcription Coactivator 1 Induces Pathological Aggression, Depression-Related Behaviors, and Neuroplasticity Genes Dysregulation in Mice
Jean-René Cardinaux, Christophe Mérinat
Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. The tra ...
Elsevier Science Inc2012Light and chronobiology: Implications for health and disease
Environmental light synchronizes the primary mammalian biological clock in the suprachiasmatic nuclei, as well as many peripheral clocks in tissues and cells, to the solar 24-hour day. Light is the strongest synchronizing agent (zeitgeber) for the circadia ...
Les Laboratories Servier2012Sex difference in the near-24-hour intrinsic period of the human circadian timing system
The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhi ...
2011The Impact of Sleep Fragmentation on Sleep Homeostasis, Brain and Peripheral Energy Metabolism and Spatial Learning
The quality of sleep has recently come to the forefront of public health concerns in industrialized nations. Indeed, voluntary sleep curtailment is widespread, sleep disorders are increasingly recognized and both correlate with the current epidemiology of ...
EPFL2011Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver
Felix Naef, Jacques Rougemont, Guillaume Rey
The mammalian circadian clock uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. While there is prominent control of liver functions by the circadian clock, the ...
2011On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver
Virtually every cell in our body tracks daily time using an endogenous mechanism called the circadian clock, which has a period of about 24 hours. This timing system offers a selective advantage by enabling organisms to anticipate periodic changes in envir ...
EPFL2011Circadian Effects of Daylighting in a Residential Environment
Marilyne Andersen, Sharon Jane Gochenour
This paper examines the effects of housing design upon the amount of natural light available for cuing of the human circadian system. It further assesses whether the conditions present in historic Boston row houses, when considered in the context of human ...
2009Exploring the transcriptional landscape of plant circadian rhythms using genome tiling arrays
BACKGROUND: Organisms are able to anticipate changes in the daily environment with an internal oscillator know as the circadian clock. Transcription is an important mechanism in maintaining these oscillations. Here we explore, using whole genome tiling arr ...
BioMed Central2009