Upper stimulation threshold for retinal ganglion cell activation
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Although signaling between neurons is central to the functioning of the brain, we still do not understand how the code used in signaling depends on the properties of synaptic transmission. Theoretical analysis combined with patch clamp recordings from pair ...
Stretch has been shown to induce electrophysiological changes in the whole heart and cardiomyocyte monolayer models. However, the mechano-electric mechanisms responsible for these changes are still not completely understood. In this project, micropatterned ...
A description of neuronal activity on the level of ion channels, as in the Hodgkin-Huxley model, leads to a set of coupled nonlinear differential equations which are difficult to analyze. In this paper, we present a conceptual framework for a reduction of ...
The inability to rapidly restore the loss of function that results from severance (cutting or crushing) of PNS and CNS axons is a severe clinical problem. As a novel strategy to help alleviate this problem, we have developed in vitro procedures using Ca2+- ...
We introduce a preconditioner for the solution of the Bidomain system governing the propagation of action potentials in the myocardial tissue. The Bidomain model is a degenerate parabolic set of nonlinear reaction-diffusion equations. The nonlinear term de ...
We present a new flexible microfabricated polyimide-based platinum array of 3D “tissue coupled electrodes” (TCEs) applied for local stimulation of the chick retinal photoreceptor layer and simultaneous patch clamp recording from a single retinal ganglion c ...
The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...
Opinions strongly diverge on what constitutes a good model of a neuron. Two lines of thought on this have coexisted for a long time: detailed biophysical models (of the style proposed in 1952 by the physiologists Alan Hodgkin and Andrew Huxley) that descri ...