Publication
Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells
Related publications (40)
Basic Mechanisms of Immunometabolites in Shaping the Immune Response
Background Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory disease. For this reason, their activation state is governed by a multitude of factors, including the metabo ...
Basel2023Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node
Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...
EPFL2023Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes
Sandrine Gerber, Qixing Zhang, Yi Wang, Léo Bühler
Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...
2022Gene expression patterns associated with multidrug therapy in multibacillary leprosy
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo
Multidrug therapy (MDT) has been successfully used in the treatment of leprosy. However, although patients are cured after the completion of MDT, leprosy reactions, permanent disability, and occasional relapse/reinfection are frequently observed in patient ...
FRONTIERS MEDIA SA2022Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters.
Sandrine Gerber, Luca Szabó, Léo Bühler
Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation to treat type 1 diabetes patients. We isolated ICC from pancreata of 14 days old juvenile piglets and characterized their maturation by immuno ...
2021Multifunctional hybrid alginate-based hydrogels for cell immobilization
Cell therapy could be a solution for many diseases that currently pose a huge health burden on patients. Especially, cell therapies based on cell microencapsulation are of great interest. Immunoprotection of cells would allow to avoid the need for immunosu ...
EPFL2020Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice
Johan Auwerx, Jun Yong Kim, Dongryeol Ryu, Ludger Jan Elzuë Goeminne
Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in r ...
2020Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles
Michele De Palma, Romain Hamelin, Bruno Torchia, Chiara Cianciaruso, Sina Nassiri, Tim Beltraminelli
Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichm ...
2019The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions
LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional control of intestinal glucocorticoid synthesis. Predominantly expressed in epithe ...
American Association for the Advancement of Science (AAAS)2019Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway Genes in Cells of the Monocyte Lineage
Paul Joseph Dyson, Romain Hamelin, Florence Armand, Isabelle Mireille Claude Schepens, Gianni Sava
Lysozyme is one of the most important anti-bacterial effectors in the innate immune system of animals. Besides its direct antibacterial enzymatic activity, lysozyme displays other biological properties, pointing toward a significant anti-inflammatory effec ...
2019