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Plasticity of Spinal Cord Reflexes After a Complete Transection in Adult Rats: Relationship to Stepping Ability

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Selective Enhancement of Motor Imagery Features Using Transcranial Direct Current Stimulation

José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Robert Leeb, Andrea Biasiucci

Transcranial Direct Current Stimulation (tDCS) has been shown to selectively modulate cortical responses in memory, motor and perceptual tasks. Here we show that this type of stimulation results in targeted enhancement of brain patterns elicited during mot ...

Graz University of Technology Publishing House2013

Recent results in spinal research are challenging the historical view that the spinal reflexes are mostly hardwired and fixed behaviours. In previous work we have shown that three of the simplest spinal reflexes could be self-organised in an agonist-antago ...

Springer Berlin Heidelberg2012

Stump nerve signals during transcranial magnetic motor cortex stimulation recorded in an amputee via longitudinal intrafascicular electrodes

Silvestro Micera, Jacopo Rigosa

Do central and peripheral motor pathways associated with an amputated limb retain at least some functions over periods of years? This problem could be addressed by evaluating the response patterns of nerve signals from peripheral motor fibers during transc ...

2011

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Michael V. Sofroniew

After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly functional and ...

2009

The importance of the in vivo dynamic nature of the circuitries within the spinal cord that generate locomotion is becoming increasingly evident. We examined the characteristics of hindlimb EMG activity evoked in response to epidural stimulation at the S1 ...

2008

For a complete adult spinal rat to regain some weight-bearing stepping capability, it appears that a sequence of specific proprioceptive inputs that are similar, but not identical, from step to step must be generated over repetitive step cycles. Furthermor ...

Elsevier2008

Facilitation of stepping with epidural stimulation in spinal rats: role of sensory input

Grégoire Courtine, Rubia van den Brand

We investigated the role of afferent information during recovery of coordinated rhythmic activity of the hindlimbs in rats with a complete spinal cord section (approximately T8) and unilateral deafferentation (T12-S2) to answer the following questions: (1) ...

2008

Step training reinforces specific spinal locomotor circuitry in adult spinal rats

Grégoire Courtine, Rubia van den Brand

Locomotor training improves function after a spinal cord injury both in experimental and clinical settings. The activity-dependent mechanisms underlying such improvement, however, are sparsely understood. Adult rats received a complete spinal cord transect ...

2008

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When a right offset vernier is immediately followed by a left offset vernier (or vice versa), only one vernier is perceived. Feature fusion has occurred. In feature fusion, observers cannot resolve the two verniers individually. Subjects perform at chance ...

2008

Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats

Grégoire Courtine

We hypothesized that epidural spinal cord stimulation (ES) and quipazine (a serotonergic agonist) modulates the excitability of flexor and extensor related intraspinal neural networks in qualitatively unique, but complementary, ways to facilitate locomotio ...

American Physiological Society2007