Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites
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[...] Low back pain affects nearly 80% the population at least once in their lifetime. Intervertebral disc (IVD) degeneration is thought to play a role in the development and onset of low back pain. The center part of the disc, the nucleus pulposus (NP), w ...
The swelling and compressive mechanical behavior as well as the morphology and biocompatibility of composite hydrogels based on Tween® 20 trimethacrylate (T3), N-vinyl-2-pyrrolidone (NVP) and nanofibrillated cellulose (NFC) were assessed in the present stu ...
Low back pain is one of the most prevailing medical concerns and can often be associated with the degeneration of the intervertebral disc. This degeneration results in a loss of biological and mechanical properties, especially a loss of viscoelastic proper ...
In Europe, low back pain (LBP) affects the quality of life of up to 30% of the active population. Although the origin of LBP is not well identified and is probably not unique, epidemiological studies suggest that the severity of the disease is correlated w ...
Currently several choices of scaffolds exist for tissue engineering purposes. Whereas a lot of works are done in the development of new material and hydrogels, very few efforts are spent for using decellularized ECM as scaffold for intervertebral disc repl ...
A polymer material system has been developed to propose an injectable, UV and in situ curable hydrogel with properties similar to the native nucleus pulposus of intervertebral disc. Neat hydrogels based on Tween® 20 trimethacrylates (T3) and N-vinyl-2-pyrr ...
The intervertebral disc (IVD), which provides flexibility to the spine and facilitates damping and motion, is composed of two distinct structures: the annulus fibrosus (AF) and the nucleus pulposus (NP). The AF, which is fibrous and elastic, confines the N ...
Background - Nucleus pulposus degeneration is a very common musculo-skeletal pathology, which is in part responsible for low back pain, a pandemic medical problem. Artificial hydrogels are being investigated by research group around the world for the purpo ...
Objective: Several cell carriers need to be selected and characterized for their compatibility with fetal cartilaginous cell survival and activity. In order to assess the in vivo regeneration capacity of fetal cartilaginous cells, these cell carriers will ...
Nowadays, the general trend towards to minimally invasive interventions is present in all the medical domains. For the surgical intervertebral spinal disc cutting or removal domain, it is particularly a necessity because the manual methods currently employ ...