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Quantitative phase imaging in biomedicine

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We introduce a new model of parametric contours defined in a continuous fashion. Our curve model relies on Hermite spline interpolation and can easily generate curves with sharp discontinuities; it also grants direct access to the tangent at each location. ...

IEEE2016

Metal Complexes as MRI Contrast Enhancement Agents

André Merbach, Lothar Helm, Eva Jakab Toth

Magnetic resonance imaging is one of the most efficient diagnostic modalities in clinical radiology and biomedical research. To enhance image contrast, paramagnetic complexes, mainly Gd3+ chelates, are used. Today, around one third of all medical MR images ...

Elsevier2015

Visualization of water drying in porous materials by X-ray phase contrast imaging

Anne Bonnin

We present in this study results from X-ray tomographic microscopy with synchrotron radiation performed both in attenuation and phase contrast modes on a limestone sample during two stages of water drying. No contrast agent was used in order to increase th ...

Wiley-Blackwell2015

Learning Approach to Optical Tomography

Michaël Unser, Demetri Psaltis, Cédric René Jean Vonesch, Ulugbek Kamilov, Alexandre Goy

Optical tomography has been widely investigated for biomedical imaging applications. In recent years optical tomography has been combined with digital holography and has been employed to produce high-quality images of phase objects such as cells. In this p ...

Optical Soc Amer2015

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Purpose As the magnetic susceptibility induced frequency shift increases linearly with magnetic field strength, the present work evaluates manganese as a phase imaging contrast agent and investigates the dose dependence of brain enhancement in comparison t ...

Wiley-Blackwell2014

Dinuclear Gd(III) Polyaminocarboxylates as Building Blocks for MRI Contrast Agents

Bibimaryam Mousavi

Magnetic resonance imaging (MRI) technique is at the forefront of biomedical and clinical imaging. Its superb spatial resolution, noninvasive nature and use of benign radiation outweigh its intrinsic low detection sensitivity. However paramagnetic relaxers ...

EPFL2013

In vivo assessment of myelination by phase imaging at high magnetic field

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Rajika Maddage

The present study evaluated the potential of using the phase of T-2* weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests ...

Elsevier2012

High-resolution cell outline segmentation and tracking from phase-contrast microscopy images

Jean-Jacques Meister, Charles Brepsant, Mark Etienne Ambühl

Accurate extraction of cell outlines from microscopy images is essential for analysing the dynamics of migrating cells. Phase-contrast microscopy is one of the most common and convenient imaging modalities for observing cell motility because it does not re ...

2012

Contrast Enhancement in Optical Coherence Microscopy

Christophe Pache

Optical Coherence Microscopy (OCM) is a three-dimensional imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue, with a high axial and lateral resolution. In OCM, a low time coherence light source is sp ...

EPFL2012

Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast

Lothar Helm, Loïck Moriggi

Magnetic resonance imaging contrast agents are currently designed by modifying their structural and physiochemical properties to improve relaxivity and to enhance image contrast. Here, we show a general method for increasing relaxivity by confining contras ...

Nature Publishing Group2010