Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting
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Homologues of Gpi8p, Gaa1p, Gpi16p, Gpi17p, and Cdc91p are essential components of the GPI transamidase complex that adds glycosylphosphatidylinositols (GPIs 1) to newly synthesized proteins in the ER. In mammalian cells, these five subunits remain stably ...
Mutations of spastin are responsible for the most common autosomal dominant form of hereditary spastic paraplegia (AD-HSP), a disease characterized by axonal degeneration of corticospinal tracts and posterior columns. Generation of polyclonal antibodies sp ...
In a simultaneous experiment we studied the de Haas–van Alphen (dHvA) and the Shubnikov–de Haas (SdH) effects in a two-dimensional electron system (2DES) in a modulation-doped GaAs∕AlxGa1−xAs heterostructure. For this, a gated 2DES mesa was monolithically ...
In mammals, the first branchial arch (BA1) develops into a number of craniofacial skeletal elements including the jaws and teeth. Outgrowth and patterning of BA1 during early embryogenesis is thought to be controlled by signals from its covering ectoderm. ...
A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...
Missense mutations and extra copies of the alpha-Synuclein gene result in Parkinson disease (PD). Human stem and progenitor cells can be expanded from embryonic tissues and provide a source of non-transformed neural cells to explore the effects of these pa ...
Due to daylight variability, a design cannot be thoroughly assessed using single-moment simulations, which is why we need dynamic performance metrics like Daylight Autonomy and Useful Daylight Illuminance. Going one step further, the annual variation in pe ...
A heterodimer of importin alpha and importin beta accomplishes the nuclear import of proteins carrying classical nuclear localization signals (NLS). The interaction between the two import factors is mediated by the IBB domain of importin alpha and involves ...
We report here the use of a specific beta-galactosidase staining assay and Northern blotting technique to examine the expression of three genes encoding either antibacterial peptides (diptericin, cecropin A) or an antifungal peptide (drosomycin) in Drosoph ...
The recessive mouse mutation kreisler affects hindbrain segmentation and inner ear development in homozygous mice. The mouse gene affected by the mutation was found to encode a basic domain leucine-zipper (bZIP)-type transcription factor of the Maf-family ...