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Neural Circuits for Goal-Directed Sensorimotor Transformations

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Most social species self-organize into dominance hierarchies(1,2), which decreases aggression and conserves energy(3,4), but it is not clear how individuals know their social rank. We have only begun to learn how the brain represents social rank(5-9) and g ...

2022

Neuromodulation of neocortical microcircuits is one of the most fascinatingand mysterious aspects of brain physiology. Despite over a century of research,the neuroscientific community has yet to uncover the fundamentalbiological organizing principles under ...

EPFL2022

The perspectives of mapping and monitoring of the sense of self in neurosurgical patients

Olaf Blanke, Bruno Herbelin, Hyeongdong Park, Sophie Jacqueline Andrée Betka, Pavo Orepic, Sixto Luis Alcoba Banqueri, Giannina Rita Iannotti

Surgical treatment of tumors, epileptic foci or of vascular origin, requires a detailed individual pre-surgical workup and intra-operative surveillance of brain functions to minimize the risk of post-surgical neurological deficits and decline of quality of ...

SPRINGER WIEN2021

Target cell-type specificity of a cortico-amygdala long range synaptic connection

Ayah Khubieh

An important function of the brain is to analyze sensory information, and to modulate animal behaviour according to previous experience. During processes of emotional learning, sensory percepts with a reinforcing quality, also called unconditioned stimuli ...

EPFL2021

Neuronal Circuits In Barrel Cortex For Whisker Sensory Perception

Carl Petersen

The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, locate objects a ...

AMER PHYSIOLOGICAL SOC2021

Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Xavier Fernandez-Real Girona

Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and ...

BMJ PUBLISHING GROUP2021

Amplified engagement of prefrontal cortex during control of voluntary action in Tourette syndrome

Sophie Jacqueline Andrée Betka

Tourette syndrome is characterized by 'unvoluntary' tics, which are compulsive, yet often temporarily suppressible. The inferior frontal gyms is implicated in motor control, including inhibition of pre-potent actions through influences on downstream subcor ...

OXFORD UNIV PRESS2020

Background Excessive and inconsolable crying behavior in otherwise healthy infants (a condition called infant colic (IC)) is very distressing to parents, may lead to maternal depression, and in extreme cases, may result in shaken baby syndrome. Despite the ...

NATURE PUBLISHING GROUP2020

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Objective: To study motor cortex plasticity after a period of training with a new prototype of bidirectional hand prosthesis in three left trans-radial amputees, correlating these changes with the modification of Phantom Limb Pain (PLP) in the same period. ...

ELSEVIER IRELAND LTD2020

The brain processes sensory information in a context- and learning-dependent manner for adaptive behavior. Through reward-based learning, relevant sensory stimuli can become linked to execution of specific actions associated with positive outcomes. The neu ...

2020