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Development of Sample-Adaptable Holders for Lightsheet Microscopy

Related publications (24)

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Fluorescent dyes are widely used for staining and visualization of DNA in optical microscopy based methods. Even though for some dyes the mechanism of binding is known, how this binding affects DNA remains poorly understood. Here we present a novel experim ...

American Chemical Society2015

Contrast Enhancement in Optical Coherence Microscopy

Christophe Pache

Optical Coherence Microscopy (OCM) is a three-dimensional imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue, with a high axial and lateral resolution. In OCM, a low time coherence light source is sp ...

EPFL2012

Guessing the fingerings from musical recordings

Paolo Prandoni, Arnaud Latty, Frederike Dümbgen

Synopsis: This project is about using musical recordings of string instruments to determine on which strings notes have been played. It includes the study of the spectral content of the recordings and the development of a robust classifica ...

2012

Stiffness Tomography by Atomic Force Microscopy

Giovanni Dietler, Sandor Kasas, Serguei Sekatski, Charles Roduit

The atomic force microscope is a convenient tool to probe living samples at the nanometric scale. Among its numerous capabilities, the instrument can be operated as a namo-indenter to gather information about the mechanical properties of the sample. In thi ...

2009

Smooth muscle Notch1 mediates neointimal formation after vascular injury

Yiming Li, Freddy Radtke

Notch1 regulates binary cell fate determination and is critical for angiogenesis and cardiovascular development. However, the pathophysiological role of Notch1 in the postnatal period is not known. We hypothesize that Notch1 signaling in vascular smooth mu ...

2009

Model-Based 2.5-D Deconvolution for Extended Depth of Field in Brightfield Microscopy

Michaël Unser, Dimitri Nestor Alice Van De Ville, François Aguet

Due to the limited depth of field of brightfield microscopes, it is usually impossible to image thick specimens entirely in focus. By optically sectioning the specimen, the in-focus information at the specimen's surface can be acquired over a range of imag ...

IEEE2008

Single molecule detection on surfaces

Marcel Leutenegger

Monitoring biological relevant reactions on the single molecule level based on fluorescence spectroscopy techniques has become one of the most promising approaches for understanding a variety of phenomena in biophysics, biochemistry and life science. By ap ...

EPFL2007

Thrombosis efficacy induced by photodynamic therapy using different photosensitizers

Bernadette Pegaz-Toquet

Various human pathologies, such as cancers or, notably, exudative age-related macular degeneration (AMD), are characterized by an abnormal vascular proliferation (angiogenesis), which in the case of this type of AMD, can rapidly lead to blindness if no cou ...

EPFL2007

Joint Texture and Topography Estimation for Extended Depth of Field in Brightfield Microscopy

Michaël Unser, Dimitri Nestor Alice Van De Ville, François Aguet

Brightfield microscopy often suffers from limited depth of field, which prevents thick specimens from being imaged entirely in-focus. By optically sectioning the specimen, the in-focus regions can be acquired over multiple images. Extended depth of field m ...

IEEE2006

Mapping the operation of the DMT continuous flow CCN counter

Athanasios Nenes

This work thoroughly analyzes a new commercial instrument for measuring Cloud Condensation Nuclei (CCN), the Droplet Measurement Technologies Cylindrical Continuous-Flow Streamwise Thermal Gradient CCN Chamber (CFSTGC). This instrument can measure CCN conc ...

2006