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Bioluminescent-based imaging and quantification of glucose uptake in vivo
Related publications (36)
New insights into rodent brain microstructure and metabolism in hepatic encephalopathy
Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...
EPFL2023Measuring Glycolytic Activity with Hyperpolarized [2H7, U-13C6] D-Glucose in the Naive Mouse Brain under Different Anesthetic Conditions
Rolf Gruetter, Bernard Lanz, Andrea Capozzi, Yves Pilloud, Emmanuelle Ines Flatt
Glucose is the primary fuel for the brain; its metabolism is linked with cerebral function. Different magnetic resonance spectroscopy (MRS) techniques are available to assess glucose metabolism, providing complementary information. Our first aim was to in ...
2021Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
Rolf Gruetter, Anders Meibom, Graham Knott, Bernard Lanz, Stéphane Laurent Escrig, Nadine Fournier, Mario Gaetano Lepore, Etienne Meylan, Louise Helene Soegaard Jensen, Inti Zlobec, Caroline Anne-Lyse Contat, Justine Pascual, Pierre-Benoit Bernard Ancey, Anouk Rossier, Silvia Sabatino
Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...
2020Optical microsystems for genetically engineered biosensors. Case study: Glucose monitoring
Diabetes is a global epidemic with millions of people dying from it every year. Progress in
microelectronics and machine learning has led to a huge number of FDA approvals of devices
for continuous monitoring and treatment of diabetes with one product usin ...
EPFL2019In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose
Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Carole Poitry-Yamate, Marta Lai, Corina Mihaela Berset
In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...
2018Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized C-13 magnetic resonance
Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment
The mammalian brain relies primarily on glucose as a fuel to meet its high metabolic demand. Among the various techniques used to study cerebral metabolism, C-13 magnetic resonance spectroscopy (MRS) allows following the fate of C-13-enriched substrates th ...
Springer Nature2017