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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
The activity of adult stem cells is essential to replenish mature cells constantly lost due to normal tissue turnover. By a poorly understood mechanism, stem cells are maintained through self-renewal while concomitantly producing differentiated progeny. He ...
2004Lentiviral Vectors for the Gene Therapy of Lympho-Hematological Disorders
Perhaps no clinical field stands to gain more from gene therapy than that of lympho-hematological disorders. First, blood cells are the site of manifestation of a large number of well-characterized monogenic hereditary defects, the correction of which woul ...
Springer Berlin Heidelberg2002Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
The ability of lentiviral vectors to transfer genes into human hematopoietic stem cells was studied, using a human immunodeficiency virus 1 (HIV-1)-derived vector expressing the green fluorescence protein (GFP) downstream of the phosphoglycerate kinase (PG ...
American Society of Hematology2000