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The Scientific Case for Brain Simulations

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Feeding the human brain model

Sean Lewis Hill

The goal of the Human Brain Project is to develop, during the next decade, an infrastructure capable of simulating a draft human brain model based on available experimental data. One of the key issues is therefore to integrate and make accessible the exper ...

Elsevier2015

Large-scale extraction of brain connectivity from the neuroscientific literature

Jean-Cédric Chappelier, Sean Lewis Hill, Martin Telefont, Renaud Luc Richardet

In neuroscience, as in many other scientific domains, the primary form of knowledge dissemination is through published articles. One challenge for modern neuroinformatics is finding methods to make the knowledge from the tremendous backlog of publications ...

Oxford Univ Press2015

The future of human cerebral cartography: a novel approach

Henry Markram, Richard Frackowiak

Cerebral cartography can be understood in a limited, static, neuroanatomical sense. Temporal information from electrical recordings contributes information on regional interactions adding a functional dimension. Selective tagging and imaging of molecules a ...

Royal Soc2015

Impact of Networked Cognition and Learning on Engineered Systems [Further Thoughts]

Ali H. Sayed

The research community is witnessing expansive efforts aimed at understanding one of the most wondrous manifestations of cognition in nature. The Blue Brain Project and the Human Brain Project in Europe are examples of ambitious drives aimed at building a ...

Institute of Electrical and Electronics Engineers2014

Interoperable atlases of the human brain

Sean Lewis Hill

The last two decades have seen an unprecedented development of human brain mapping approaches at various spatial and temporal scales. Together, these have provided a large fundus of information on many different aspects of the human brain including micro- ...

Elsevier2014

Neuroscience thinks big (and collaboratively)

Henry Markram

Despite cash-strapped times for research, several ambitious collaborative neuroscience projects have attracted large amounts of funding and media attention. In Europe, the Human Brain Project aims to develop a large-scale computer simulation of the brain, ...

Nature Publishing Group2013

The Green's function formalism as a bridge between single- and multi-compartmental modeling

Willem Anna Mark Wybo, Benjamin Torben-Nielsen

Neurons are spatially extended structures that receive and process inputs on their dendrites. It is generally accepted that neuronal computations arise from the active integration of synaptic inputs along a dendrite between the input location and the locat ...

Springer Berlin Heidelberg2013

Seven challenges for neuroscience

Henry Markram

Although twenty-first century neuroscience is a major scientific enterprise, advances in basic research have not yet translated into benefits for society. In this paper, I outline seven fundamental challenges that need to be overcome. First, neuroscience h ...

2013

Computational Neuroscience Breakthroughs Through Innovative Data Management

Anastasia Ailamaki, Thomas Heinis, Farhan Tauheed, Sadegh Heyrani Nobari, Laurynas Biveinis

Simulations have become key in many scientific disciplines to better understand natural phenomena. Neuroscientists, for example, build and simulate increasingly fine grained models (including subcellular details, e.g., neurotransmitter) of the neocortex to ...

2013

Predictive Engineering the Membrane Composition of Neocortical Neurons

Georges Khazen

The brain is the most mysterious and intricate biological structure known to man. It dominates the way we live, think, reason and behave. It is built of billions of neurons that communicate with each other through trillions of connections using electrical ...

EPFL2011