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Integrated Nanophotonic Biosensors for Point-of Care Diagnostics and Bioanalytical Applications

Related publications (33)

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Microfluidic beamscanning optical leaky-wave antenna concept

Julien Perruisseau-Carrier, Juan Sebastian Gomez Diaz

The concept of a reconfigurable optical leaky-wave antenna (LWA) based on microfluidics technology is presented. The host waveguide is composed of a microfluidic channel which is periodically loaded by a set of silicon corrugations. The refractive index of ...

2014

Automated Analysis of Rare Biomarkers Using a Magnetic Bead Surface Coverage Assay Coupled with Chaotic Mixing on a Microfluidic Chip

Hüseyin Cumhur Tekin

Extremely sensitive protein detection is crucial for early diagnosis and monitoring of diseases. Present day’s limit of detection for an antibody-antigen recognition-based immunoassay in serum without having to use special target antigen amplification tech ...

EPFL2012

Design, Fabrication and Characterization of Mid-Infrared Strip Waveguide for Laser Spectroscopy in Liquid Environments

Yu-Chi Chang

Optical sensors based on the interaction between molecular vibrations and mid infrared radiations attracted high attentions in the last decades. In this study, we present the development of a waveguide evanescent field sensor based on the absorption spectr ...

EPFL2012

From Particles to Pillars

Josias Basil Wacker

Metal oxide nanoparticles and their applications (e.g. in nano-electronics, nano-optics or drug delivery) have seen a growing interest in the past decades. Traditional procedures to synthesize, functionalize and integrate nanoparticles in devices mostly ha ...

EPFL2012

Cocaine detection by a mid-infrared waveguide integrated with a microfluidic chip

Nico de Rooij, Hans Peter Herzig, Peter Van der Wal, Vincent Paeder, Lubos Hvozdara, Philip Wägli, Yu-Chi Chang, Joab Di Francesco

A germanium (Ge) strip waveguide on a silicon (Si) substrate is integrated with a microfluidic chip to detect cocaine in tetrachloroethylene (PCE) solutions. In the evanescent field of the waveguide, cocaine absorbs the light near 5.8 mm, which is emitted ...

Royal Soc Chemistry2012

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We might be at the turning point where research in microfluidics undertaken in academia and industrial research laboratories, and substantially sponsored by public grants, may provide a range of portable and networked diagnostic devices. In this Progress R ...

Wiley-Blackwell2011

We presented a pneumatically tunable 2 x 2 optofluidic switch for on-chip light routing that was controlled by compressed air. The device was fabricated with an optically clear elastomer-polydimethylsiloxane ( PDMS)-by soft-lithography. The optical switchi ...

Royal Society of Chemistry2011

Further advances in molecular medicine and cell biology also require new electrochemical systems to detect disease biomarkers and therapeutic compounds. Microelectronic technology offers powerful circuits and systems to develop innovative and miniaturized ...

2010

Micro-optics for multiple laser trapping in microfluidics

Fabrice Merenda

Optical trapping allows manipulating very small objects – varying from Angstöms to micron size particles – without physical contact by taking advantage of laser light. This technique, relying on light momentum transfer, allows manipulating biological matte ...

EPFL2008

Circuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy

Giovanni De Micheli, Sandro Carrara, Jacopo Olivo, Luca Benini, Andrea Cavallini

Drug development and personalized therapy require accurate and frequent monitoring of the metabolic response by living tissues to treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitori ...

IEEE2008