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An Interactive Gameplay to Crowdsource Multiple Sequence Alignment of Genome Sequences: Genenigma

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Synthesis of 4-nitrophenyl sulfones and application in the modified Julia olefination

Jieping Zhu

4-Nitrophenyl (NP) sulfones were successfully employed in the modified Julia olefination reaction with carbonyl compds. The olefination reaction proceeds through a sequence of aldol addn., Smiles rearrangement, and elimination. The sulfones are easily prep ...

2006

Molecular characterization of key enzymes involved in dehalorespiration with tetrachloroethene

Julien Maillard

Chloroethenes, and most particularly tetra- (PCE) and trichloroethene (TCE) are major groundwater pollutants due to their extensive industrial use as solvents since the 1920s. The strong electronegativity of the chlorines renders them very stable under aer ...

EPFL2004

Signal search analysis server

Giovanna Ambrosini, Philipp Bucher

Signal search analysis is a general method to discover and characterize sequence motifs that are positionally correlated with a functional site (e.g. a transcription or translation start site). The method has played an instrumental role in the analysis of ...

2003

APDB: a novel measure for benchmarking sequence alignment methods without reference alignments

Philipp Bucher

MOTIVATION: We describe APDB, a novel measure for evaluating the quality of a protein sequence alignment, given two or more PDB structures. This evaluation does not require a reference alignment or a structure superposition. APDB is designed to efficiently ...

2003

Numerous potentially functional but non-genic conserved sequences on human chromosome 21

Philipp Bucher

The use of comparative genomics to infer genome function relies on the understanding of how different components of the genome change over evolutionary time. The aim of such comparative analysis is to identify conserved, functionally transcribed sequences ...

2002

Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv

Stewart Cole

Original genome annotations need to be regularly updated if the information they contain is to remain accurate and relevant. Here the complete re-annotation of the genome sequence of Mycobacterium tuberculosis strain H37Rv is presented almost 4 years after ...

2002

Comparative mycobacterial genomics as a tool for drug target and antigen discovery

Stewart Cole

Genomics and the associated downstream technologies are generating vast data sets that provide new opportunities for understanding and combating both infectious and genetic diseases in humans. The genomic approach has been applied to tuberculosis, a major ...

2002

The integrated genome map of Mycobacterium leprae

Stewart Cole

The integrated map of the Mycobacterium leprae genome unveiled for the first time the genomic organization of this obligate intracellular parasite. Selected cosmid clones, isolated from a genomic library created in the cosmid vector Lorist6, were identifie ...

2002

Genomics of Mycobacterium bovis

Stewart Cole

The imminent completion of the genome sequence of Mycobacterium bovis will reveal the genetic blueprint for this most successful pathogen. Comparative analysis with the genome sequences of M. tuberculosis and M. bovis BCG promises to expose the genetic bas ...

2001

A cSNP map and database for human chromosome 21

Philipp Bucher

Single nucleotide polymorphisms (SNPs) are likely to contribute to the study of complex genetic diseases. The genomic sequence of human chromosome 21q was recently completed with 225 annotated genes, thus permitting efficient identification and precise map ...

2001