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Objective Morphological Classification of Neocortical Pyramidal Cells

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Synaptic connectivity between neurons is naturally constrained by the anatomical overlap of neuronal arbors, the space on the axon available for synapses, and by physiological mechanisms that form synapses at a subset of potential synapse locations. What i ...

Oxford University Press (OUP)2017

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex

Michele Giugliano

Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and di ...

Cell Press2017

Artificial spatiotemporal touch inputs reveal complementary decoding in neocortical neurons

Silvestro Micera

Investigations of the mechanisms of touch perception and decoding has been hampered by difficulties in achieving invariant patterns of skin sensor activation. To obtain reproducible spatiotemporal patterns of activation of sensory afferents, we used an art ...

Nature Publishing Group2017

Rich cell-type-specific network topology in neocortical microcircuitry

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Idan Segev, Eyal Gal, Michael London

Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a similar to 0.3-mm(3) volum ...

Nature Publishing Group2017

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Gioele La Manno

The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature.Here,we have use ...

2015

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local ...

Frontiers Research Foundation2015

Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than roden ...

Public Library Science2014

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A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based ...

Nature Publishing Group2013

Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex

Carl Petersen, Yves Emile Alfred Kremer

Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in ...

Nature Publishing Group2012

Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms

Wulfram Gerstner, Carl Petersen, Richard Naud, Skander Mensi, Christian Antonio Pozzorini, Michael Avermann

Mensi S, Naud R, Pozzorini C, Avermann M, Petersen CCH, Gerstner W. Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms. J Neurophysiol 107: 1756-1775, 2012. First published December 7, 2011; do ...

American Physiological Society2012