Publication
Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration
Related publications (81)
Evaluating contrast sensitivity in early and intermediate age-related Macular Degeneration with the Quick Contrast Sensitivity Function
Michael Herzog, Simona Adele Garobbio
Purpose: The purpose of this study was to describe, validate, and compare the contrast sensitivity functions (CSFs) acquired with the novel quick CSF (qCSF) method from patients with early and intermediate age-related macular degeneration (eAMD and iAMD) a ...
2023In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes
Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Mathieu Künzi
Objective: To image healthy retinal pigment epithelial (RPE) cells in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of RPE cell features as a function of age, axial length (AL), and eccentricity. Design: Single-center, explorator ...
ELSEVIER2022POLYRETINA restores light responses in vivo in blind Gottingen minipigs
Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Paola Vagni, Elodie Geneviève Zollinger, Charles-Henri Puncho Jérôme Vila, Golnaz Sherafatipour
Retinal prostheses hold potential for artificial vision in blind people. Here, authors show that POLYRETINA, a large and high-density photovoltaic epiretinal device, restores light-evoked cortical responses in blind Gottingen minipigs at safe irradiance le ...
NATURE PORTFOLIO2022Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools
Henning Paul-Julius Stahlberg, Dongchun Ni
Type I CRISPR-Cas systems typically rely on a two-step process to degrade DNA. First, an RNA-guided complex named Cascade identifies the complementary DNA target. The helicase-nuclease fusion enzyme Cas3 is then recruited in trans for processive DNA degrad ...
CELL PRESS2022Photovoltaic stimulation of retinal microcircuit for vision restoration
Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...
EPFL2021Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas
Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais
Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to indepen ...
2021OCT-angiography assessing quiescent and active choroidal neovascularization in retinitis pigmentosa associated with PRPH2 pathogenic variant
Purpose: To report multimodal imaging findings including optical coherence tomography angiography (OCT-A) of a patient presenting with a quiescent choroidal neovascularization (CNV) in one eye and an active CNV in the fellow eye, complicating retinitis pig ...
2021In vivo evaluation of gene editing and prosthetic strategies to restore vision in small and large animal models of retinal degeneration
Inherited retinal diseases (IRDs) form a group of diverse disorders that lead to the degeneration of the light-sensing cells of the retina: the photoreceptors. IRDs are among the leading causes of blindness in working-age adults living in industrialized co ...
EPFL2020Development of a new visual prosthesis for preclinical studies on artificial vision
Marta Jole Ildelfonsa Airaghi Leccardi
The technological evolution in materials science and microengineering favored the production of advanced visual prostheses useful for fighting blindness and to improve patients quality of life. Visual prostheses aim at replacing lost visual functions by ar ...
EPFL2020Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell
Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais
Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light called phosphenes, which allows them to perform visually guided tasks, such as orientation, navigation, object recognition, object manipulation and reading. H ...
2020