MATHICSE Technical Report : Integrated Heart – Coupling multiscale and multiphysics models for the simulation of the cardiac function
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Recent evidence suggests that the heart possesses a greater regeneration capacity than previously thought. In the present study, we isolated undifferentiated precursors from the cardiac nonmyocyte cell population of neonatal hearts, expanded them in cultur ...
The cardiovascular system can be macro-modelled as a collection of coupled oscillators. Recently, the use of mutual couplings of these oscillators to characterize the state of the system during anaesthesia has been proposed. Assuming that the synchronizati ...
GLUT8 is a glucose transporter isoform expressed at high levels in testis; at intermediate levels in the brain, including the hippocampus; and at lower levels in the heart and several other tissues. GLUT8 is located in an intracellular compartment and does ...
In this work we present a mathematical model for the coupling of cardiovascular system and metabolism under sport efforts. Effects such as oxygenation, heart rates, flow rates, blood pressure and mass transfer to tissues will be considered. A special atten ...
The quantitative assessment of cardiac motion is a fundamental concept to evaluate ventricular malfunction. We present a new optical-flow-based method for estimating heart motion from two-dimensional echocardiographic sequences. To account for typical hear ...
Plakophilins are proteins of the armadillo family that function in embryonic development and in the adult, and when mutated can cause disease. We have ablated the plakophilin 2 gene in mice. The resulting mutant mice exhibit lethal alterations in heart mor ...
Background—Objective, quantitative, segmental noninvasive/bedside measurement of cardiac motion is highly desirable in cardiovascular medicine, but current technology suffers from significant drawbacks, such as subjectivity of conventional echocardiographi ...
We propose a new global registration method for estimating the cardiac displacement field in 2D sequences of ultrasound images of the heart. The basic idea is to select a reference frame (e.g., the first image of a cycle) and to map each image in the seque ...
It is known that extracardiac factors (nervous, humoral, and hemodynamic) participate in the power-law behavior of heart-rate variability. To assess whether intrinsic properties of cardiac tissue might also be involved, beat- rate variability was studied i ...
In this article we propose a cardiac motion estimation technique that uses non-rigid registration to compute the dense cardiac displacement field from 2D ultrasound sequences. Our method employs a semi-local deformation model which provides controlled smoo ...
