Publication
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
Related publications (43)
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex comp ...
ANNUAL REVIEWS2023AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets
AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...
EPFL2022Dissecting the role of the mitochondrial carrier SLC25A47
Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...
EPFL2022Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance
A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...
NATURE PORTFOLIO2022Dissecting the role of the asparagine synthesis in acute liver injury
Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...
EPFL2022Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology
Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun
Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...
2021Radical-free hyperpolarized MRI using endogenously occurring pyruvate analogues and UV-induced nonpersistent radicals
Rolf Gruetter, Andrea Capozzi, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Alice Radaelli, Claudia Christina Zanella, Lionel Pierre Arn
It was recently demonstrated that nonpersistent radicals can be generated in frozen solutions of metabolites such as pyruvate by irradiation with UV light, enabling radical-free dissolution dynamic nuclear polarization. Although pyruvate is endogenous, the ...
WILEY2021Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
Johan Auwerx, Richardus Houtkooper
Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. Objectives: We aimed to investigate the effects of 6 wk NR ...
OXFORD UNIV PRESS2020Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis
Kristina Schoonjans, Jian Liu, Bhoomika Mathur
Background & Aims: Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases. Methods: We performed high-throughput sequencing of ...
2020Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data
Vassily Hatzimanikatis, Vikash Kumar Pandey
Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic steatohepatitis. To identify the deregulation that occurs in metabolic processes at ...
2019