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Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

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Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

Functional Perturbation of the Gab2 Multiprotein Complex by High-affinity SH2-binding Monobodies in Chronic Myelogenous Leukemia

Unexpected Off-Targets and Paradoxical Pathway Activation by Kinase Inhibitors

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm

Mechanisms of resistance to BCR-ABL and other kinase inhibitors

Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis