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Extra-axonal restricted diffusion as an in-vivo marker of reactive microglia

Related publications (34)

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Integrating smart algorithms on neural devices presents significant opportunities for various brain disorders. In this paper, we review the latest advancements in the development of three categories of intelligent neural prostheses featuring embedded signa ...

arXiv2024

Beyond Quiescent and Active: Intermediate Microglial Transcriptomic States in a Mouse Model of Down Syndrome

Cèsar-Lluis Sierra Noguera

Research on microglia in Down syndrome (DS) has shown that microglial activation, increased inflammatory gene expression, and oxidative stress occur at different ages in DS brains. However, most studies resulted in simplistic definitions of microglia as qu ...

Basel2024

RibSeg v2: A Large-Scale Benchmark for Rib Labeling and Anatomical Centerline Extraction

Jiancheng Yang, Jason Ken Adhinarta, Ming Li

Automatic rib labeling and anatomical centerline extraction are common prerequisites for various clinical applications. Prior studies either use in-house datasets that are inaccessible to communities, or focus on rib segmentation that neglects the clinical ...

Piscataway2024

T1-weighted structural MRI is widely used to measure brain morphometry (e.g., cortical thickness and subcortical volumes). Accelerated scans as fast as one minute or less are now available but it is unclear if they are adequate for quantitative morphometry ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...

EPFL2023

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero

Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...

NATURE PORTFOLIO2022

Backgrounds: Multiple sclerosis (MS) is an inveterate phlogistic situation characterized by focal and vaguely diffusive de-myelination and neurodegeneration, in the sphere of central nervous system (CNS). The brain's chronic inflammatory reaction includes ...

IMR PRESS2022

Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?

Jordan Squair

Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as "reactive astrogliosis." Diversity in ...

2021

Fronto-Temporal Disconnection Within the Presence Hallucination Network in Psychotic Patients With Passivity Experiences

Olaf Blanke, Alessandra Griffa, Jevita Potheegadoo, Patric Hagmann, Kim Do, Nathan Quentin Faivre, Roy Salomon, Giulio Rognini, Eva Blondiaux, Giedre Stripeikyte, Pierre Progin

Psychosis, characterized by hallucinations and delusions, is a common feature of psychiatric disease, especially schizophrenia. One prominent theory posits that psychosis is driven by abnormal sensorimotor predictions leading to the misattribution of self- ...

2021

Traumatic brain injuries is one of the major cause of death and disability worldwide especially among young people. The initial injury can later develop into a secondary injury that is particularly lethal. The patient’s survival relies on fast and proper a ...

2021