Publication
Nucleic acids presenting polymer nanomaterials as vaccine adjuvants
Related publications (64)
Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection
Nicola Harris, Julia Esser-von Bieren
Over 25% of the world's population are infected with helminth parasites, the majority of which colonise the gastrointestinal tract. However, no vaccine is yet available for human use, and mechanisms of protective immunity remain unclear. In the mouse model ...
Public Library of Science2015Engineering synthetic vaccines using cues from natural immunity
Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attac ...
Nature Publishing Group2013Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose
Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Ziad Julier
In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after int ...
Natl Acad Sciences2013Peptide-Based Vaccinology: Experimental and Computational Approaches to Target Hypervariable Viruses through the Fine Characterization of Protective Epitopes Recognized by Monoclonal Antibodies and the Identification of T-Cell-Activating Peptides
Matteo Dal Peraro, Matteo Castelli
Defining immunogenic domains of viral proteins capable of eliciting a protective immune response is crucial in the development of novel epitope-based prophylactic strategies. This is particularly important for the selective targeting of conserved regions s ...
Hindawi Publishing Corporation2013TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice
Pedro Miguel Nunes Pereira de Almeida Reis, Andrea Pfeifer, Marija Vukicevic, Andreas Muhs, Valérie Gafner, Anna Lucia Buccarello
Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide ...
Amer Soc Hematology2013Brillouin distributed fibre sensing using phase modulated probe
Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Xin Lu
A novel configuration for a Brillouin distributed sensor using a phase modulated probe is presented. It offers the combined advantages of a direct implementation using simple devices and a large immunity to noise, shifting the information from the baseband ...
Spie-Int Soc Optical Engineering2013Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems
New generation vaccines, which are subunit vaccines, have considerably improved safety profiles, but are often poorly immunogenic, especially when administered through mucosal routes. Also, the diversity of the mechanisms of action of infectious pathogens ...
EPFL2012Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes
Jeffrey Alan Hubbell, Melody Swartz, Armando Stano
While current subunit vaccines successfully induce humoral immune responses, a need exists for vaccine strategies to elicit strong cell-mediated immunity to address diseases such as cancer and chronic viral infection. Polymersomes are stable vesicles compo ...
2012Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial
Understanding how human genetic variation impacts individual response to immunogens is fundamental for rational vaccine development. To explore host mechanisms involved in cellular immune responses to the MRKAd5 human immunodeficiency virus type 1 (HIV-1) ...
2011PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration
Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Armando Stano
Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...
Elsevier2011