Lactate measurement by neurochemical profiling in the dorsolateral prefrontal cortex at 7T: accuracy, precision, and relaxation times
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The trends in the design of image sensors are to build sensors with low noise, high sensitivity, high dynamic range, and small pixel size. How can we benefit from pixels with small size and high sensitivity? In this dissertation, we study a new image senso ...
Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate (below 0.3 μmol/g) during visual stimulation. These studies have been limited to the visual cortex because of its high energy metabolism and ...
Wunderlich K, Beierholm UR, Bossaerts P, O'Doherty JP. The human prefrontal cortex mediates integration of potential causes behind observed outcomes. J Neurophysiol 106: 1558-1569, 2011. First published June 22, 2011; doi: 10.1152/jn.01051.2010.-Prefrontal ...
2011
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In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process and assembled with glutamate biosensor microprobes1. It enables local delivery of specific liquids into brain tissue for the stimulation or ...
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Lactate production is monitored in industrial processes as a crucial metabolite for cultured mammalian cells. Typically lactate is strongly produced during the exponential growth phase, while its net consumption is frequently observed when cells enter into ...
Elsevier2013
Behavioral studies have long shown that humans solve problems in two ways, one intuitive and fast (System 1, model-free), and the other reflective and slow (System 2, model-based). The neurobiological basis of dual process problem solving remains unknown d ...
Elsevier2011
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The dentato-thalamo-cortical tract (DTCT) connects the lateral cerebellum with contralateral motor and nonmotor areas, such as the primary motor cortex (M1), the ventral premotor cortex (PMv), and the dorsolateral prefrontal cortex (DLPFC). As the acquisit ...
Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain injury (ABI) patients monitored with cerebral microdialysis (CMD). Sixty episodes of GD (defined a ...
The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate that becom ...
In this paper, we consider model combination methods for adaptive filtering that perform unbiased estimation. In this widely studied framework, two adaptive filters are run in parallel, each producing unbiased estimates of an underlying linear model. The o ...
