Publication
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Related publications (19)
Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle
The progressive decline of muscle mass and function called sarcopenia is a multi-factorial process associated to frailty, disability, and low quality of life in the elderly. The co-factor nicotinamide adenine dinucleotide (NAD+) becomes a limiting factor i ...
EPFL2019The gut microbiota influences skeletal muscle mass and function in mice
Johan Auwerx, Hongbo Zhang, Walter Wahli
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...
AMER ASSOC ADVANCEMENT SCIENCE2019Protocol for the PreventIT feasibility randomised controlled trial of a lifestyle-integrated exercise intervention in young older adults
Kamiar Aminian, Anisoara Ionescu
Introduction The European population is rapidly ageing. In order to handle substantial future challenges in the healthcare system, we need to shift focus from treatment towards health promotion. The PreventIT project has adapted the Lifestyle-integrated Ex ...
BMJ2019Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen
Elise Marie Catherine Vinckenbosch
Magnetic resonance at ultra-high field increases signal and spectral dispersion. In this thesis, I use those characteristics to investigate three different subjects in 13C spectroscopy, hyperpolarized methods and chemical exchange saturation transfer (CEST ...
EPFL2018Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh
A T4-like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo-controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit of coliphages through the ...
Wiley-Blackwell2017Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
Johan Auwerx, Maria del Carmen Sandi Perez, Patrick Aebischer, Laurent Mouchiroud, Pénélope Andreux, Dongryeol Ryu, Evan Graehl Williams, Elena Katsyuba, Norman Lionel Moullan, Pooja Jha, Damien Sébastien Huzard, Giuseppe Lo Sasso
The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...
Nature Publishing Group2016Type 5 adenylyl cyclase disruption leads to enhanced exercise performance
Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper, Jie Zhang
The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (beta-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exerc ...
Wiley-Blackwell2015Molecular and cell-based therapies for muscle degenerations: a road under construction
Marco Cassano, Stefania Crippa
Despite the advances achieved in understanding the molecular biology of muscle cells in the past decades, there is still need for effective treatments of muscular degeneration caused by muscular dystrophies and for counteracting the muscle wasting caused b ...
Frontiers Research Foundation2014Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism
The mechanisms involved in the coordinate regulation of the metabolic and structural programs controlling muscle fitness and endurance are unknown. Recently, the nuclear receptor PPAR beta/delta was shown to activate muscle endurance programs in transgenic ...
American Society for Clinical Investigation2013