Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex
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Background: Population aging is posing multiple social and economic challenges to society. One such challenge is the social and economic burden related to increased health care expenditure caused by early institutionalizations. The use of modern pervasive ...
The use of daylight in buildings is important because it contributes to energy savings by reducing the use of electric lighting and space heating. It also impacts on biological functions and on well-being. Indeed, light not only allows vision, but has non- ...
Nightshift work can negatively impact sleep, performance, and health. Careful manipulation of light exposure patterns can help reduce these negative effects but is challenging in conditions of rapidly rotating shiftwork and due to individual differences. A ...
Gene expression in eukaryotes is a complex multi-step process. It starts in the nucleus with transcription, the synthesis of a mRNA copy from a DNA template. While in the nucleus, the RNA transcript is subject to multiple co- and post-transcriptional modif ...
Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...
Nightshift work can negatively impact sleep, performance, and health. Careful manipulation of light exposure patterns can help reduce these negative effects but is challenging in conditions of rapidly rotating shiftwork and due to individual differences. A ...
As suggested by the conservation of resources theory, in contemporary societies time is considered as a limited resource in the same way as money and energy. In the current paper, a novel daily rhythm approach related to motility is presented, in order to ...
The circadian clock regulates diurnal variations in autonomic thermoregulatory processes such as core body temperature in humans. Thus, we might expect that similar daily fluctuations also characterize human thermal perception, the ultimate role of which i ...
Our exposure to light has a key role in regulating our biological clock through a dedicated photoreceptor present in the human eye. Increased awareness to its criticality when it comes to human well-being is urgently needed, as this criticality is potentia ...