Study of brain metabolic dysfunctions in animal models of mood disorder using magnetic resonance spectroscopy
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Objective: The cellular basis of variable symptoms in Huntington disease (HD) is unclear. One important possibility is that degeneration of the interneurons in the cerebral cortex, which play a critical role in modulating cortical output to the basal gangl ...
Conversational social video is becoming a worldwide trend. Video communication allows a more natural interaction, when aiming to share personal news, ideas, and opinions, by transmitting both verbal content and nonverbal behavior. However, the automatic an ...
Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. The tra ...
Elsevier Science Inc2012
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Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...
EPFL2012
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Visual backward masking is a very sensitive tool for studying early visual processing deficits and a reliable endophenotype of schizophrenia. Mental diseases strongly overlap in many aspects, for example, in psychopathology, cognition, and genetics. Here, ...
Pion Ltd.2012
Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human dise ...
Recent genetic, behavioral, and clinical studies suggest that functional psychoses (schizophrenia, bipolar disorder, schizoaffective disorder), previously thought to be distinct from each other, may belong to one continuum. The shine-through masking paradi ...
Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...
Adolescence is characterized by major developmental changes that may render the individual vulnerable to stress and the development of psychopathologies in a sex-specific manner. Earlier we reported lower anxiety-like behavior and higher risk-taking and no ...
Neuroligins (NLGNs) are cell adhesion molecules that are important for proper synaptic formation and functioning and are critical regulators of the balance between neural excitation/inhibition (E/I). Mutations in NLGNs have been linked to psychiatric disor ...