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Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs

Related publications (32)

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Niobium nitride (NbN) is a particularly promising material for quantum technology applications, as it shows the degree of reproducibility necessary for large-scale superconducting circuits. We demonstrate that resonators based on NbN thin films present a o ...

2023

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

Natalia Gasilova, Jean-Manuel Segura, David Viertl

Template-directed methods are emerging as some of the most effective means to conjugate payloads at selective sites of monoclonal antibodies (mAbs). We have previously reported a method based on an engineered Fc-III reactive peptide to conjugate a radionuc ...

Cambridge2023

Compact, Spatial-mode-interaction-free, Ultralow-loss, Nonlinear photonic integrated circuits

Tobias Kippenberg, Rui Ning Wang, Xinru Ji, Zheru Qiu, Junqiu Liu, Jijun He

We implement Euler bends to build compact high-Q Si3N4 racetrack microresonators, featuring a small footprint of only 0.21 mm(2) for 19.8 GHz FSR. We demonstrate that these multi-mode microresonators can be operated in the single-mode regime and generate a ...

IEEE2022

In this thesis, we study the stochastic heat equation (SHE) on bounded domains and on the whole Euclidean space

\R^d.

We confirm the intuition that as the bounded domain increases to the whole space, both solutions become arbitrarily close to one another ...

EPFL2022

The modeling of non-covalent interactions, solvation effects, and chemical reactions in complex molecular environment is a challenging task. Current state-of-the-art approaches often rely on static computations using implicit solvent models and harmonic ap ...

EPFL2022

Estimate on the Dimension of the Singular Set of the Supercritical Surface Quasigeostrophic Equation

Maria Carola Colombo, Silja Noëmi Aline Haffter

We consider the SQG equation with dissipation given by a fractional Laplacian of order α

2021

A combinatorial proof of a sumset conjecture of Furstenberg

Florian Karl Richter

We give a new proof of a sumset conjecture of Furstenberg that was first proved by Hochman and Shmerkin in 2012: if

\log r / \log s

is irrational and

X

and

Y

are

\times r

- and

\times s

-invariant subsets of

[0,1]

, respectively, then $\dim_\text{ ...

2021

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

Sandrine Gerber, Céline Marie Anne Journot, Laura Camille Louise Nicolle

Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chem ...

2021

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We address the problem of minimizing a smooth function f0(x) over a compact set D defined by smooth functional constraints fi(x)≤0, i=1,…,m given noisy value measurements of fi(x). This problem arises in safety-critical applications, where certain paramete ...

2019

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The system and method for used capsules (11), such as coffee capsules, with a lid and a capsule body, comprises at least cutting means (17) to cut the lid from the body, capturing means to extract the cut lid from the body, compacting means (12, 14) to com ...

2018

In this thesis, we study the stochastic heat equation (SHE) on bounded domains and on the whole Euclidean space

\R^d.

We confirm the intuition that as the bounded domain increases to the whole space, both solutions become arbitrarily close to one another ...

EPFL2022

A combinatorial proof of a sumset conjecture of Furstenberg

Florian Karl Richter

We give a new proof of a sumset conjecture of Furstenberg that was first proved by Hochman and Shmerkin in 2012: if

\log r / \log s

is irrational and

X

and

Y

are

\times r

- and

\times s

-invariant subsets of

[0,1]

, respectively, then $\dim_\text{ ...

2021