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SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres
Related publications (35)
Requirements for DNA bubble structure for efficient cleavage by helix-two-turn-helix DNA glycosylases
Oxidative DNA lesions, constantly generated by both endogenous and environmentally induced reactive oxygen species, are removed via the base excision repair pathway. In bacteria, Fpg and Nei DNA glycosylases, belonging to the helix-two-turn-helix (H2TH) st ...
2020A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice
Double-strand breaks (DSBs) are the most toxic type of DNA lesions. Cells repair these lesions using either end protection- or end resection-coupled mechanisms. To study DSB repair choice, we present the Color Assay Tracing-Repair (CAT-R) to simultaneously ...
2020RADX: A novel single-stranded DNA-binding protein regulating telomere recombination
Telomeres are specialized nucleoprotein structures present at the ends of linear chromosome. The telomeric DNA part is comprised of 5-15 kilo base pairs of double stranded TTAGGG repeats and it contains at the 3' end a single-stranded G-rich overhang of 50 ...
EPFL2019Functional analysis of the telomeric long non-coding RNA TERRA
Telomeres are nucleoprotein structures present in the end of linear chromosomes. In humans, a core complex of 6 proteins cap and protect the chromosome ends from being recognized as double-strand breaks and eliciting unwanted DNA damage and repair response ...
EPFL2019Expression and differential regulation of human TERRA at several chromosome ends
Joachim Lingner, Marianna Feretzaki, Patricia Renck Nunes
The telomeric long noncoding RNA TERRA has been implicated in regulating telomere maintenance by telomerase and homologous recombination, and in influencing telomeric protein composition during the cell cycle and the telomeric DNA damage response. TERRA tr ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2019Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveilla ...
Springer2019Repair as Practice and Knowledge. An Ethnography of Two Repair Cafés
Current repair initiatives, from networks of repair cafés run by local volunteers to community-turned-company iFixit, have been very successful at putting questions of repair and maintenance at the forefront of public debate. However, they have done so in ...
2019The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors
Telomeres are dynamic nucleo-protein structures capping the ends of all eukaryotic chromosomes. Together with telomerase, they counteract replication-dependent telomere attrition. Additionally, they disguise the linear ends of the chromosome from the DNA d ...
EPFL2018Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage
Gérald Joseph Paul Lossaint, Katarina Bacevic
Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1. Yet Cdk2 also has non-redundant functions that can be revealed in certain genetic ...
Springer Nature2017TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection
The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps similar to 90 bp of DNA through several lysine and arginine residues localiz ...
Cell Press2016