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Innovative Techniques and Strategies for a Reliable High-Throughput Genotoxicity Assessment
Related publications (32)
Preomic profile of BxPC-3 cells after treatment with BRC4
BRCA2 and RAD51 are two proteins that play a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. BRCA2 assists RAD51 fibrillation and defibrillation through binding with its eight BRC repeats, with BRC4 being one of the ...
ELSEVIER2023Safety climate in university laboratories. Part I: model development and practical application
Safety climate assessment has become a regular practice for most organisations. However, it is often limited to questionnaires, providing only qualitative information. The indicator-based approach takes precedence over decision-making, and practical risk a ...
2023Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis
Michele De Palma, Nahal Mansouri
Aims: Understanding the correlations between underlying medical and personal characteristics of a patient with cancer and the risk of lung metastasis may improve clinical management and outcomes. We used machine learning methodologies to predict the risk o ...
2023Risk assessment of waterborne viruses for recreational sites in Lake Geneva
Tamar Kohn, Xavier Fernandez Cassi, Chaojie Li, Timothy R. Julian
Norovirus is the most acute species among the viruses studied according to the simulations while enterovirus poses the least danger. The relative distance to the contamination sources, wind conditions as well as inactivation rates are essential in determin ...
2022Principles of checkpoint override
Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...
EPFL2022Integrative transcriptome analyses of Transposable Elements (TEs) and genes contribute to a better understanding of colorectal cancer
Cancer is the second leading cause of death worldwide. Cancer develops through multiple hallmark functions including apoptosis evasion, unlimited replicative potential, metastasis, and immune avoidance. Over the past few decades, researchers have reported ...
EPFL2022Semi-quantitative Model for Risk Assessment in University Laboratories
University chemical laboratories, contrary to common perception, are dangerous working environments. Unlike industry, where most processes are standardized, in academia, they are modified so frequently that in-depth and detailed risk assessment becomes unf ...
Springer, Cham2021NanoSafe III: A User Friendly Safety Management System for Nanomaterials in Laboratories and Small Facilities
Thierry Meyer, Anna Maria Novello, Alke Fink, Elina Buitrago
Research in nanoscience continues to bring forward a steady stream of new nanomaterials and processes that are being developed and marketed. While scientific committees and expert groups deal with the harmonization of terminology and legal challenges, risk ...
2021Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis
Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...
EPFL2020A risk-based multi-level stress test methodology: application to six critical non-nuclear infrastructures in Europe
Anton Schleiss, Daniela Rodrigues, José Pedro Gamito de Saldanha Calado Matos
Recent natural disasters that seriously affected critical infrastructure (CI) with significant socio-economic losses and impact revealed the need for the development of reliable methodologies for vulnerability and risk assessment. In this paper, a risk-bas ...
2020