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Virucidal nanoparticles and use thereof against influenza virus
Related publications (32)
Expiratory Aerosol pH: The Overlooked Driver of Airborne Virus Inactivation
Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler
Respiratory viruses, including influenza virus and SARS-CoV-2, are transmitted by the airborne route. Air filtration and ventilation mechanically reduce the concentration of airborne viruses and are necessary tools for disease mitigation. However, they ign ...
2022Virucidal compositions and use thereof
Francesco Stellacci, Paulo Henrique Jacob Silva, Valeria Cagno, Özgün Kocabiyik
The invention relates to virucidal compositions comprising a sialic acid (SA) moiety, pharmaceutical compositions and disinfection and/or sterilization compositions comprising thereof and uses thereof in disinfection and/or sterilization methods and in tre ...
2021Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir
Francesco Stellacci, Paulo Henrique Jacob Silva, Chiara Medaglia
Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics. Influenza viruses also possess a high genetic variabi ...
2021Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo
Francesco Stellacci, Paulo Henrique Jacob Silva, Valeria Cagno, Özgün Kocabiyik, Yong Zhu, Chiara Medaglia
Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antiviral ...
WILEY2020Contact networks across ages: computational analysis of epidemiological dynamics
For decades mathematical modeling in epidemiology has helped understanding the dynamics of infectious diseases, as well as describe possible intervention scenarios to prevent and control them. However, such models were relying on several assumptions, such ...
EPFL2020Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Jacques Fellay, Rui Yang, Jie Chen, Yu Zhang, Xavier Duval, Peng Zhang, Qian Zhang, Zhiyong Liu, Juan Li
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF ...
AMER ASSOC ADVANCEMENT SCIENCE2020Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses
Francesco Stellacci, Matteo Gasbarri, Valeria Cagno, Chiara Medaglia
Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteogly ...
AMER SOC MICROBIOLOGY2020Enhancing daily light exposure increases the antibody response to influenza vaccination in patients with dementia
Jean-Louis Scartezzini, Mirjam Münch
Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we tested whether a greater long-term daily light exposure supports the immune response to the annual influenza vaccin ...
Cold Spring Harbor Laboratory Press2020Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
Suliana Manley, Christian Sieben
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment factor (AF). Since sialic acid alone cannot fulfill ...
2020Virucidal nanomaterials against influenza
Influenza affects millions of people in all parts of the world. The fact that influenza virus can spread through air increases the chance of influenza outbreaks. There are 3 to 5 million severe cases of influenza resulting in 290,000 to 650,000 deaths ever ...
EPFL2019