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Since its isolation by Esther Lederberg, phage lambda and its repressor protein CI have contributed substantially to the advancement of molecular biology. In this issue of Cell Host & Microbe, Silpe et al. (2020) characterize the antirepressor Qtip of Vibrio phage VP882, which through CI sequestration triggers a lytic switch.
Christian Heinis, Xudong Kong, Camille Villequey