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What are you synching about? Emerging complexity of Notch signaling in the segmentation clock
Related publications (32)
How are cells instructed to form somite boundaries by the zebrafish segmentation clock?
In vertebrate embryos, the elongating body axis is patterned via the sequential and rhyth-mic production of segments from a posterior unsegmented tissue called the presomitic mesoderm (PSM). This process is controlled by a population of cellular oscillator ...
EPFL2023Patterning and mechanics of somite boundaries in zebrafish embryos
Andrew Charles Oates, Sundar Ram Naganathan
The body axis of vertebrates is subdivided into repetitive compartments called somites, which give rise primarily to the segmented architecture of the musculoskeletal system in the adult body. Somites form in a sequential and rhythmic manner in embryos and ...
2020Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation
How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control segmentation of the presomitic mesoderm (PSM). In mouse embryos, this molecular clock comprises signalin ...
2018Delta-Notch signalling in segmentation
Modular body organization is found widely across multicellular organisms, and some of them form repetitive modular structures via the process of segmentation. It's vastly interesting to understand how these regularly repeated structures are robustly genera ...
Elsevier Sci Ltd2017Faster embryonic segmentation through elevated Delta-Notch signalling
An important step in understanding biological rhythms is the control of period. A multicellular, rhythmic patterning system termed the segmentation clock is thought to govern the sequential production of the vertebrate embryo's body segments, the somites. ...
Nature Publishing Group2016Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
Patrick Fraering, Mitko Dimitrov, Hermeto Gerber, Maria Luna Perciato, Jingjing Chen, Andrea Rinaldi
Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of ...
Nature Publishing Group2016Generation of dispersed presomitic mesoderm cell cultures for imaging of the zebrafish segmentation clock in single cells
Andrew Charles Oates, Daniele Soroldoni
Segmentation is a periodic and sequential morphogenetic process in vertebrates. This rhythmic formation of blocks of tissue called somites along the body axis is evidence of a genetic oscillator patterning the developing embryo. In zebrafish, the intracell ...
2014Interplay between intercellular signaling and cell movement in development
Cell movement and local intercellular signaling are crucial components of morphogenesis during animal development. Intercellular signaling regulates the collective movement of a cell population via direct cell-cell contact. Cell movement, conversely, can i ...
2014Wnt-regulated dynamics of positional information in zebrafish somitogenesis
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells ...
2014Notch Signaling in Pigment Cells and Generation of Mouse Models for Ocular Diseases
Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival and differentiation. In melanocytes, Notch signaling is essential for the maintenance of melanocytes and the melanocyte stem cell population. Whereas, ...
EPFL2013